The Center for Advanced Drug Research (CADRE) at SRI Shenandoah Valley in Harrisonburg, Virginia has a mission to

• Improve the productivity of the pharmaceutical industry

• Help our nation respond to biothreats

• Develop life-saving treatments for neglected and orphan diseases

CADRE combines SRI's expertise in drug discovery, computational biology, and preclinical development with proteomics—the analysis of biological proteins, including those present in pathogens.

The Center focuses on several program areas:

• Proteomics studies of host-vector-pathogen interactions: Client projects include studies of insect-borne viruses, respiratory and diarrheal pathogens, and parasitic protozoa for diseases such as West Nile fever, dengue fever, tuberculosis, Leishmaniasis, and malaria.

• Identification of "critical links" underlying antibiotic resistance, intracellular toxin transport, and vector competence: Our approaches enable the discovery of novel markers, well-characterized targets, and therapies.

• Biomarkers discovery: We apply innovative approaches to identify and characterize biomarkers. Projects include research on developing sensitive methods to diagnose fungal infections and discovering novel biomarkers for drugs in development for companion therapies and companion diagnostics.

• Drug discovery: Projects include research on metabolic disorders such as insulin resistance, osteoporosis, and for infectious diseases.