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Biosciences Publications, Presentations, Abstracts, and Patents

  2007

Jump to: Biophysics | Cancer Biology | Genetics | Infectious Disease | Medicinal Chemistry | Neuroscience | Pharmaceutical Sciences |Toxicology| Other |

Biophysics

Publications

Blakely, E.A., and P.Y. Chang. A review of ground-based heavy ion radiobiology relevant to space radiation risk assessment: I. Cataracts and CNS effects. Adv Space Res 40(9):1307–1319, 2007. 

Blakely, E.A., and P.Y. Chang. A review of ground-based heavy ion radiobiology relevant to space radiation risk assessment: II. Cardiovascular and immunological effects. Adv Space Res 40:461–469, 2007.

Chang, P.Y., J. Bakke, and A. Puey. Fractionated exposure of high energy iron ions spares tissue damage in vivo. Adv Space Res 40:568–575, 2007.

Chang, P.Y., J. Roelands, J. Schindler-Horvat, and R.L. Sheets. Toxicity testing of vaccines. In Nonclinical Drug Safety Assessment: Practical Considerations for Successful Registrations. W. Sietsema and R. Schwen, Eds. FDAnews, Washington, DC, 2007.

Chang, P.Y., K.A. Bjornstad, C.J. Rosen, S. Lin, and E.A. Blakely. Particle radiation alters expression of matrix metalloproteases resulting in ECM remodeling in human lens cells. Radiat Environ Biophysics 46(2):187–94, 2007.

Abstracts and Presentations

Blakely, E.A., P.Y. Chang, K.A. Bjornstad, and C.J. Rosen. Particle radiation alters expression of matrix metalloproteases resulting in ECM remodeling in human lens cells. 18th Annual NASA Space Radiation Investigators’ Workshop. Rohnert Park, CA, July 13–15, 2007.

Blakely, E.A., P.Y. Chang, K.A. Bjornstad, and C.J. Rosen. Particle radiation alters expression of matrix metalloproteases resulting in ECM remodeling in human lens cells. Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting. Ft. Lauderdale, FL, May 6–10, 2007.

Blakely, E.A., P.Y. Chang, R.I. Schwarz, K.A. Bjornstad, C.J. Rosen, R. Khatua , C.L. Wisnewski, B. Parvin, and A.C. Thompson. Bystander response to an X-ray microbeam using three different DNA damage response markers in epithelial cells. International Congress for Radiation Research. San Francisco, CA, July 8–12, 2007.

Chang, P.Y., J. Bakke, S. Lin, and A. Puey. Effects of particle LET and dose fractionation on tissue-specific mutations in vivo. International Congress for Radiation Research. San Francisco, CA, July 8–12, 2007.

Chang, P.Y. Spectral Analysis of mutations in tissues after particle radiation. 18th Annual NASA Space Radiation Investigators’ Workshop. Rohnert Park, CA, July 13–15, 2007.

Durbin, P.W., E.A. Blakely, D.K. Shuh, P.Y. Chang, and K. Raymond. Biomimetic lanthanide & actinide decorporation agents: preclinical development. International Congress for Radiation Research. San Francisco, CA, July 8–12, 2007.

Cancer Biology

Publications

Lin, Y.C., L. You, Z. Xu, B. He, C.T. Yang, J.K. Chen, I. Mikami, G. Clement, Y. Shi, K. Kuchenbecker, J. Okamoto, M. Kashani-Sabet, and D.M. Jablons. Wnt inhibitory factor-1 gene transfer inhibits melanoma cell growth. Hum Gene Ther 18:379–386, 2007.*

Rasmussen, L.M., N.T. Zaveri, J. Stenvang, R.H. Peters, and A.E. Lykkesfeldt. A novel dual-target steroid sulfatase inhibitor and antiestrogen: SR16157, a promising agent for the therapy of breast cancer. Breast Cancer Res Treat [Epub ahead of print], February 1, 2007.

Shi, Y., B. He, K.M. Kuchenbecker, L. You, Z. Xu, I. Mikami, A. Yaqui-Beltran, G. Clement, Y.C. Lin, J. Okamoto, D.T. Bravo, and D.M. Jablons. Inhibition of Wnt-2 and galectin-3 synergistically destabilizes beta-catenin and induces apoptosis in human colorectal cancer cells. Int J Cancer 121:1175–1181, 2007.*

Shi, Y., B. He, L. You, and D.M. Jablons. Roles of secreted frizzled-related proteins in cancer. Review. Acta Pharmacol Sin 28:1499–1504, 2007.*

* These articles were submitted for publication before Dr. Shi joined SRI in June 2007.

Abstracts and Presentations

Choy, G.S., W.-R. Chao, D.A. Rizzieri, A. Rosowsky, M. Ramirez, and G. Bank. Combination talotrexin (PT-523) with paclitaxel in A549 non-small cell lung cancer (NSCLC) athymic nude mice xenografts. AACR 98th Annual Meeting. Los Angeles, CA, April 14–18, 2007.

Hobbs, P., W.-R. Chao, K. Amin, D. Yean, T. Le, M. Tanga, and M. Tanabe. SR16388 inhibits STAT3 activation and angiogenesis in lung cancer model. AACR 98th Annual Meeting. Los Angeles, CA, April 14–18, 2007.

Hobbs, P., W.-R. Chao, K. Amin, K. Laderoute, C. Green, T. Le, T. Parman, B. Sato, M. Tanga, D. Yean, and M. Tanabe. SR16388, a novel steroidal anti-tumor agent, inhibits non-small cell lung tumor and prostate tumor growth and angiogenesis. 14th International Molecular Medicine Tri-Conference. San Francisco, CA, Feb. 27–March 2, 2007.

Jong, L. SR13654: An orally active anticancer agent potently inhibits nuclear survivin expression and suppresses tumor growth in animal models. AACR 98th Annual Meeting. Los Angeles, CA, April 14–18, 2007.

Pan, C.-P., J. P. Haushalter, K. Amin, Z. Haroon, and G.W. Faris. Fluorescent tissue transglutaminase substrates for tumor boundary imaging—a novel strategy is developed to image tumor boundaries optically to help surgeons in determining how wide a margin to remove. The Optical Society of America (OSA) Annual Meeting, Frontiers in Optics (FiO). San Jose, CA, September 16–20, 2007.

Parvin, B., N. Ghosh, L. Heiser, M. Knapp, C. Talcott, K. Laderoute, J. Gray, and P. Spellman. Spectral decomposition of signaling networks. IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology. Honolulu, HI, April 1–5, 2007.

Shi, Y., B. He, K.M. Kuchenbecker, L. You, Z. Xu, I. Mikami, A. Yaqui-Beltran, G. Clement, Y.C. Lin, J. Okamoto, D.T. Bravo, and D.M. Jablons. Inhibition of Wnt-2 and galectin-3 synergistically destabilizes beta-catenin and induces apoptosis in human colorectal cancer cells. Traditional Wnt Meeting. San Diego, CA, .June 2007.*

Tiwari, A., C. Talcott, M. Knapp, P. Lincoln, and K. Laderoute. Analyzing biological pathways using SAT-based approaches. Second International Conference on Algebraic Biology. Hagenberg, Austria, July 2–4, 2007.

Yean, D., W.-R. Chao, K. Amin, and L. Jong. SR13654: An orally active anticancer agent potently inhibits nuclear survivin expression and suppresses tumor growth in animal models. AACR 98th Annual Meeting. Los Angeles, CA, April 14–18, 2007.

Yean, D., W.-R. Chao, K. Amin, C. Green, and L. Jong. Novel dietary indole analogs for prostate cancer treatment: Managing prostate cancer with quality of life considerations. Innovative Minds in Prostate Cancer Today (IMPaCT) Meeting. Atlanta, GA, September 5–8, 2007.

Yean, D., W.-R. Chao, C. Green, J. Bakke, and L. Jong. SR13668: A novel dietary indole analog blocks growth factor stimulated Akt activation and cell proliferation in various cancer cell lines. AACR 98th Annual Meeting. Los Angeles, CA, April 14–18, 2007.

*This poster was submitted before Dr. Shi joined SRI in June 2007.

Genetics

Publications

An, P., L.H. Wang, H. Hutcheson-Dilks, G. Nelson, S. Donfield, J.J. Goedert, C.R. Rinaldo, S. Buchbinder, G.D. Kirk, S.J. O’Brien, and C.A. Winkler. Regulatory polymorphisms in the cyclophilin A gene, PPIA, accelerate progression to AIDS. PloS Pathogen 3(6):e88, 2007.

Doppalapudi, R.S., E.S. Riccio, L.L. Rausch, J.A. Shimon, P.S. Lee, K.E. Mortelmans, I.M. Kapetanovic, J.A. Crowell, and J.C. Mirsalis. Evaluation of chemopreventive agents for genotoxic activity. Mutat Res 629:148–160, 2007.

Lind, J.M., H. Hutcheson-Dilks, S.M. Williams, M. Essex, S.S. Tishkoff, S.J. O’Brien, and M.W. Smith. Elevated male European and female African contributions to the genomes of African American individuals. Hum Genet 120(5):713–722, 2007.

Lin, Y.C., L. You, Z. Xu, B. He, C.T. Yang, J.K. Chen, I. Mikami, G. Clement, Y. Shi, K. Kuchenbecker, J. Okamoto, M. Kashani-Sabet, and D.M. Jablons. Wnt inhibitory factor-1 gene transfer inhibits melanoma cell growth. Hum Gene Ther 18:379–386, 2007.*

*This article was submitted for publication before Dr. Shi joined SRI in June 2007.

Infectious Disease

Publications

Mirsalis, J.C. Editorial: The new R&D landscape of orphan and neglected infectious diseases. Drug Disc News. p. 13, September 2007.

Vaidyanathan, R., and T.W. Scott. Geographic variation in vector competence for West Nile virus in the Culex pipiens (Diptera: Culicidae) complex in California. Vector borne Zoonotic Dis 7(2):193–198 2007.

Warhurst, D.C., J.C. Craig, I.S. Adagu, R.K. Guy, P.B. Madrid, and Q.L. Fivelman. Activity of piperaquine and other 4-aminoquinoline antiplasmodial drugs against chloroquine-sensitive and resistant blood-stages of Plasmodium falciparum: Role of beta-haematin inhibition and drug concentration in vacuolar water- and lipid-phases. Biochem Pharmacol [Epub ahead of print], March 19, 2007.

Abstracts and Presentations

Held, D.M., A.C. Shurtleff, C. Green, J.M. Fong, R. Buelow, and R.L. Burke. Neutralization of Botulinum neurotoxin serotype B with antibodies produced in rabbit. 44th Annual Interagency Botulism Research Coordinating Committee (IBRCC) Meeting. Asilomar, CA, October 14–18, 2007.

Matsuyama, K., L. Hokama, J. Cisneros, A. Bettridge, T. Tran, L. Olson, M. Tanga, and K. Mortelmans. Antimicrobial activity produced by various compounds against virulent biodefense organisms. SIM (Society for Industrial Microbiology) Meeting. Denver, CO, July 29–August 2, 2007.

Shurtleff, A.C., D.M. Held, J. Shimon, C. Green, J.M. Fong, R. Buelow, and R.L. Burke. Neutralizing Botulinum neurotoxin with human polyclonal antibodies from transgenic rabbits. 44th Annual Interagency Botulism Research Coordinating Committee (IBRCC) Meeting, Asilomar, CA, October 14–18, 2007.

Medicinal Chemistry

Publications

Chao, W. R., D. Yean, K. Amin, C. Green, and L. Jong. Computer-aided rational drug design: a novel agent (SR13668) designed to mimic the unique anticancer mechanisms of dietary indole-3-carbinol to block Akt signaling. J Med Chem 50:3412–3415, 2007.

Dawson, M.I., Z. Xia, G. Liu, J.A. Fontana, L. Farhana, B.B. Patel, S. Arumugarajah, M. Bhuiyan, X.K. Zhang, Y.H. Han, W.B. Stallcup, J. Fukushi, T. Mustelin, L. Tautz, Y. Su, D.L. Harris, N. Waleh, P.D. Hobbs, L. Jong, W.R. Chao, L.J. Schiff, and B.P. Sani. An adamantyl-substituted retinoid-derived molecule that inhibits cancer cell growth and angiogenesis by inducing apoptosis and binds to small heterodimer partner nuclear receptor: effects of modifying its carboxylate group on apoptosis, proliferation, and protein-tyrosine phosphatase activity. J Med Chem 50:2622–2639, 2007.

Frank, G.D., L. Jong, N. Collins, and E.G. Spack. Nonprofit model for drug discovery and development. Drug Dev Res 68:186–196, 2007.

Jacob, J., S. Cabarcas, I. Veras, N. Zaveri, and L. Schramm. The green tea component EGCG inhibits RNA polymerase III transcription. Biochem Biophys Res Commun 360:778–783, 2007.

Jozwiak, K., C. Khalid, M.J. Tanga, I. Berzetei-Gurske, L. Jimenez, J.A. Kozocas, A. Woo, W. Zhu, R.-P. Xiao, D.R. Abernethy, and I.W. Wainer. Comparative molecular field analysis of the binding of the stereoisomers of fenoterol and fenoterol derivatives to the beta-2 adrenergic receptor. J Med Chem 50(12):2903–2915, 2007.

Khroyan, T.V., W.E. Polgar, J. Orduna, N.T. Zaveri, A.K. Judd, D.J. Tuttle, A. Sanchez, and L. Toll. Anti-nociceptive and anti-allodynic effects of a high affinity NOP hexapeptide [Ac-RY(3-CI)YRWR-NH2] (Syn 1020) in rodents. Eur J Pharmacol 560:29–35, 2007.

Khroyan, T.V., N.T. Zaveri, W.E. Polgar, J. Orduna, C. Olsen, F. Jiang, and L. Toll. SR16435 [1-(1-(bicyclo[3.3.1]nonan-9-yl)piperidin-4-yl)indolin-2-one], a novel mixed nociceptin/orphanin FQ/mu-opioid receptor partial agonist: analgesic and rewarding properties in mice. J Pharmacol Exp Ther 320:934–943, 2007.

Madrid, P.B., W.E. Polgar, L. Toll, and M.J. Tanga. Synthesis and antitubercular activity of phenothiazines with reduced binding to dopamine and serotonin receptors. Bioorg Med Chem Lett 17:3014–3017, 2007.

Moos, W.H. Strategy and drug research (Chapters 2.01–2.27). In Comprehensive Medicinal Chemistry II (2nd Edition), Vol II: Strategy and Drug Research. J.B. Taylor and D.J. Triggle, Eds. W.H. Moos, Vol. 2 Ed., 1–1087. Elsevier, Oxford, UK, 2007.

Moos, W.H. Preface to Volume 2. In Comprehensive Medicinal Chemistry II (2nd Edition), Vol II: Strategy and Drug Research. J.B. Taylor and D.J. Triggle, Eds. W.H. Moos, Vol. 2 Ed., xxi–xxii. Elsevier, Oxford, UK, 2007.

Zaveri, N.T., and B. J. Murphy. Nuclear hormone receptors (Chapter 2.25). In Comprehensive Medicinal Chemistry II (2nd Edition), Vol II: Strategy and Drug Research. J.B. Taylor and D.J. Triggle, Eds. W.H. Moos, Vol. 2 Ed. Elsevier, Oxford, UK, 2007.

Neuroscience

Publications

Flores, A.E., J.E. Flores, H. Deshpande, J.A. Picazo, X.M. Xie, P. Franken, H.C. Heller, D.A. Grahn, and B.F. O’Hara. Pattern recognition of sleep in rodents using piezoelectric signals generated by gross body movements. IEEE Trans Biomed Eng 54:225–233, 2007.

Kilduff, T.S., S.R. Morairty, T.L. Steininger, and X.M. Xie. Hypocretin, GABAB receptors and sleep. In Narcolepsy and Hypersomnia, C. Bassetti, M. Billiard, and E. Mignot, Eds, 375–386. Marcel Dekker, Inc., New York, 2007.

Rawls, S.M., J.A. Schroeder, Z. Ding, T. Rodriguez, and N. Zaveri. NOP receptor antagonist, JTC-801, blocks cannabinoid-evoked hypothermia in rats. Neuropeptides 41:239–247, 2007.

Spagnolo, B., G. Calo, W.E. Polgar, F. Jiang, C.M. Olsen, I. Berzetei-Gurske, T.V. Khroyan, S.M. Husbands, J.W. Lewis, L. Toll, and N.T. Zaveri. Activities of mixed NOP and mu-opioid receptor ligands. Br J Pharmacol [Epub ahead of print], December 3, 2007.

Wisor, J.P., M. Striz, J. DeVoss, G.M. Murphy, Jr., D.M. Edgar, and B.F. O’Hara. A novel quantitative trait locus on mouse chromosome 18, “era1,” modifies the entrainment of circadian rhythms. Sleep 30(10):1255-63, 2007.

Xie, X.M., A.L. Van Deusen, I. Vitko, P.Q. Barrett, N. Huynh, H. Cheng, N. Yang, and E. Perez-Reyes. Validation of high throughput screening assays against three subtypes of Cav3 T-type channels using molecular and pharmacologic approaches. Assay Drug Dev Technol 5.2:191–203, 2007.

Xie, X.M., D. Pardi, and J. Black. Molecular and cellular actions of γ-hydroxybutyric acid (GHB): Possible mechanisms underlying GHB efficacy in narcolepsy. In Narcolepsy and Hypersomnia, C. Bassetti, M. Billiard, and E. Mignot, Eds, 583–620. Marcel Dekker, Inc., New York, 2007.

Abstracts and Presentations

Foreman, M.M., M. Eller, X.M. Xie, K. Wilcox, H. White, and J. Stables. Preclinical pharmacological properties of JZP-4, a novel and potent anticonvulsant. Soc Neurosci Abstr P166.2, 2007.

Gerashchenko, D., C.L. Thompson, J.P. Wisor, L. Ng, A. Jones, E. Lein, and T.S. Kilduff. Gene expression patterns in the locus coeruleus during sleep/wakefulness: microarray analysis. Sleep 30:A369, 2007.

Gerashchenko, D., C. Thompson, J.P. Wisor, L. Ng, K. Smith, A. Jones, T. Kilduff, and E. Lein. Gene expression patterns in the locus coeruleus during sleep/wakefulness: microarray analysis. Sleep 2007. Mineapolis, MN, June 9–14, 2007.

Gerashchenko, D., J.P. Wisor, J. Hara, M. Hassan, and T.S. Kilduff. TRH induces locomotor activity via activation of hypocretin-containing neurons. Society for Neuroscience Annual Meeting. San Diego, CA, November 3–7, 2007.

Gerashchenko, D., J.P. Wisor, J. Hara, M. Hassan, and T.S. Kilduff. TRH induces locomotor activity via activation of hypocretin-containing neurons. Program No. 735.18. Abstract Viewer/Itinerary Planner. Washington DC: Society for Neuroscience, 2007.

Hara, J., X.M. Xie, T. Sakurai, and T.S. Kilduff. Thyrotropin-releasing hormone excites hypocretin/orexin neurons via pre- and post-synaptic mechanisms. Program No. 471.16. Abstract Viewer/Itinerary Planner. Washington DC: Society for Neuroscience, 2007.

Hara, J., X.M. Xie, T. Sakurai, and T.S. Kilduff. Thyrotropin-releasing hormone directly excites hypocretin/orexin neurons in the mouse hypothalamus. Sleep Res APSS Abstr 069, 2007.

Hara, J., X.M. Xie, T. Sakurai, and T.S. Kilduff. Thyrotropin-releasing hormone directly excites hypocretin/orexin neurons in the mouse hypothalamus. Sleep 30:A23, 2007.

Lein, E., C.L. Thompson, S. Pathak, L. Ng, L. Kuam, J.P. Wisor, D. Gerashchenko, K. Smith, S. Fischer, S. Pathak, M. Hawrylycz, A. Jones, and T.S. Kilduff. Global dynamics of gene expression following sleep deprivation in mice. Program No. 771.3. Abstract Viewer/Itinerary Planner. Washington DC: Society for Neuroscience, 2007.

Lein, E., C.L. Thompson, S. Pathak, L. Ng, L. Kuan, J.P. Wisor, D. Gerashchenko, K. Smith, S. Fischer, M. Hawrylycz, A. Jones, and T.S. Kilduff. Global dynamics of gene expression following sleep deprivation in mice. Society for Neuroscience Annual Meeting. San Diego, CA, November 3–7, 2007.

Morairty, S.R., J. Moreau, K. Silveira, J.G. Wettstein, and T.S. Kilduff. The effect of the hypocretin receptor antagonist ACT-078573 on sleep during the active period in Sprague-Dawley rats. Program No. 199.11. Abstract Viewer/Itinerary Planner. Washington DC: Society for Neuroscience, 2007.

Thompson, C., J.P. Wisor, D. Gerashchenko, S. Fischer, S. Pathak, M. Hawrylycz, A. Jones, T. Kilduff, and E. Lein. Identification of genes with immediate-early-like activation in brain following sleep deprivation. WorldSleep07, a meeting of the World Federation of Sleep Research and Sleep Medicine Societies. Cairns, Queensland, Australia, September 2–6, 2007.

Thompson, C., J.P. Wisor, D. Gerashchenko, S. Fischer, S. Pathak, M. Hawrylycz, A. Jones, T. Kilduff, and E. Lein. Mapping of neuronal activity by immediate early gene expression during sleep deprivation and recovery sleep. Sleep 2007. Mineapolis, MN, June 9–14, 2007.

Thompson, C.L., J.P. Wisor, D. Gerashchenko, S. Fischer, S. Pathak, M. Hawrylycz, A. Jones, T.S. Kilduff, and E. Lein. Mapping of neuronal activity by immediate early gene expression during sleep deprivation and recovery sleep. Sleep 30:A118, 2007.

Xie, X.M., J. Wisor, J. Hara, R. LeWinter, T. Crowder, T.V. Khroyan, A. Yamanaka, S. Diano, T. Horvath, T. Sakurai, L. Toll, and T.S. Kilduff. Dual modulation of stress-induced analgesia by hypocretin/orexin and nociceptin/orphanin FQ. Soc Neurosci Abstr P747.23, 2007.

Xie, X., J.P. Wisor, J. Hara, R. LeWinter, T. Crowder, T.V. Khroyan, A. Yamanaka, T. Sakurai, S. Diano, T. Horvath, L. Toll, and T.S. Kilduff. Opposing modulation of stress-induced analgesia by hypocretin/orexin and nociceptin/orphanin FQ. Society for Neuroscience Annual Meeting. San Diego, CA, November 3–7, 2007.

Pharmaceutical Sciences

Articles

Wang, J., C. Yang, E. Wang, S. Li, N. Zaveri, and P. Liu. Chromatographic analysis and decomposition product characterization of compound SR 16157 (NSC 732011). J Pharm Biomed Anal 45:572–582, 2007.

Abstracts and Presentations

Bejugam, N., H.J. Parish, and G. Shankar. Development and optimization of tablets loaded with liquid permeation enhancer. American Association of Pharmaceutical Scientists (AAPS) Annual Meeting and Exposition. San Diego, CA, November 11–15, 2007.

Green, C.E., and H.J. Parish. CounterACT preclinical development facility. NIH 1st Annual Countermeasures Against Chemical Threats (CounterACT) Network Research Symposium. Arlington, VA, April 25–27, 2007.

Shankar, G., V. Pavuluri, H.J. Parish, J. Bakke, R. Swezey, C. Green, and M. Ussery. In situ oral drug absorption studies on paromomycin in presence of permeation enhancers in rats. American Association of Pharmaceutical Scientists (AAPS) Annual Meeting and Exposition. San Diego, CA, November 11–15, 2007.

Shankar, G. Development of improved DTPA for radionuclide chelation: Transport enhancers. National Institute of Allergy and Infectious Diseases (NIAID) Workshop: Medical Countermeasures Against Radiological and Nuclear Threats. Bethesda, MD, September 17–18, 2007.

Shankar, G.N., L. Nguyen, H.J. Parish, M. Ussery, and V. Pavuluri. Developing an oral product for poorly absorbed paromomycin for treatment and prevention of opportunistic infections. International Symposium on Recent Advances in Drug Delivery Systems. Salt Lake City, UT, Feb 26–28, 2007.

Yang, C., J. Wang, A. Cheung, V. Krishnamoorthi, E. Wang, S. Li, and P. Liu. Validated HPLC assay and decomposition product identification of tanespimycin (17-allylamino-17-demethoxygeldanamycin or 17-AAG). American Association of Pharmaceutical Scientists (AAPS) Annual Meeting and Exposition. San Diego, CA, November 11–15, 2007.

Toxicology

Publications

Wolff, R., Persson, H., Lalonde, G., Melton, S., Perkins, K., Pfeiffer, J., Sweeney, T., Rothenberg, S., and Vuillemenot, B. Inhalation Toxicology. In Nonclinical Drug Safety Assessment, Practical Considerations for Successful Registration. W. Sietsema and R. Schwen, Eds. FDAnews, Washington, DC, 2007.

Abstracts and Presentations

Alt, C., T. Harrison, A. Matsukawa, C. Litterst, J. Mirsalis, and A. D’Andrea. Vaginal cytokine production as biomarkers for the safety evaluation of microbicide-induced vaginal irritation. 37th Annual Meeting of the German Society of Immunology. Heidelberg, Germany, September 5–8, 2007.

Alt, C., T. Harrison, N. Fujita, K. Shew, T. Tran, A. Matsukawa, C. Litterst, J. Mirsalis, and A. D’Andrea. CCL2/monocyte-chemoattractant protein 1 as a novel biomarker for the safety evaluation of microbicide-induced vaginal irritation. 15th Annual Meeting of the International Cytokine Society. San Francisco, CA, October 26–30, 2007.

Erickson, R.I., E.B. Defensor, D.R. Middaugh, J.C. Mirsalis, and K.L. Steinmetz. Preliminary neurological and 8 arm radial maze (8ARM) assessments after treatment with the antimalarial, b-arteether (bAE), to neonatal and adult rats. Society for Toxicology Abstract. March 2007.

Erickson, R.I., E.B. Defensor, R.L. Garcia, D.R. Middaugh, M. Mangels, J.C. Mirsalis, and K.L. Steinmetz. Preliminary neurological and 8-arm radial maze (8ARM) tasks during treatment with scopolamine (SCO), nicotine (NIC), ethanol (ETH), or amphetamine (AMP). The Toxicologist. Abstract 1487, 2007.

Erickson, R.I., E.B. Defensor, D.R. Middaugh, J.A. Nimer, J.C. Mirsalis, and K.L. Steinmetz. Preliminary neurological and 8-arm radial maze (8ARM) assessments after treatment with the antimalarial, b-arteether (bAE) to neonatal and adult rats. The Toxicologist. Abstract 1488, 2007.

Rausch, L., P. Catz, S. LeValley, L. Dousman, K.L. Steinmetz, C. Green, J. Tomaszewski, K. Schweikart, N. Zaveri, and J.C. Mirsalis. Biomarker levels in hormonally sensitive female F-344 rat tissues after 28-day daily oral gavage treatment with SR16157, a selective estrogen receptor modulator (SERM). SOT, 46th Annual Meeting. Charlotte, NC, March 25–29, 2007.

Rausch, L., P. Catz, S. LeValley, L. Dousman, K.L. Steinmetz, C. Green, J. Tomaszewski, K. Schweikart, N. Zaveri, and J.C. Mirsalis. Biomarker levels in hormonally sensitive female F-344 rat tissues after 28-daily oral gavage treatment with SR16157, a selective estrogen receptor modulator (SERM). The Toxicologist. Abstract 409, 2007.

 Other Publications, Abstracts, and Presentations

Moos, W.H. The intersection of strategy and drug research, Chapter 2.01. In Comprehensive Medicinal Chemistry II (2nd Edition), Vol II: Strategy and Drug Research. J.B. Taylor and D.J. Triggle, Eds. W.H. Moos, Vol. 2 Ed., 1–84. Elsevier, Oxford, UK, 2007.

Moos, W.H. SRI Shenandoah Valley—It doesn’t get any better than this. Shenandoah Valley Technology Council Tech Nite 7.0. Harrisonburg, VA, May 30, 2007.

Moos, W.H. New strategic opportunities in research. Dow Jones Venture Wire Health Care Innovations 2007. Redwood City, CA, June 20, 2007.

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       Last Updated Dec 2, 2010