Radiation Toxicology

We perform GLP and non-GLP radiation toxicology studies as either stand-alone services or as part of a comprehensive development package. Throughout a study we perform weekly clinical examinations, including alterations in teeth, nose, eyes, perineum, gross motor and behavioral changes, and monitor body weights, and water and food consumption. Depending on your needs, we can perform:

• Clinical pathology
• Blood collection for plasma analysis
• Assays for cytogenetic damage
• Organ weights
• Histopathology
• Molecular biology-based studies in tissues:
• Colony forming unit measurements in spleen and gut
• Studies with late effects end-points, such as radiation-induced cataractogenesis, that are dose dependent and may take up to 30 weeks to develop
• Studies on the long-term effects of radiation on behavior and cognition.

For a printer-friendly description, please download "Evaluating Drug Effects on Radiation Efficacy and Toxicity" (PDF - 57k)

Facilities
Our irradiation facilities have both a Pantak HF320 X-ray source and a Mark 1-68A 137Cs gamma emission source. These facilities are used for both in vitro and in vivo studies. In addition to whole body animal irradiation, focal irradiation is accomplished by using specially designed holders. Animals are housed under veterinary care in a modern AAALAC-accredited facility. All our procedures and facilities are routinely audited and maintained under GLP regulations. SRI has an in-house model shop that can custom design and manufacture holders to our client's specifications.

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     Last Updated Jul 17, 2008