Contact SRI Biosciences

In Vivo Assessment of Pain

SRI currently offers in vivo models for Acute and Neuropathic Pain, including Inflammatory Models of Hyperalgesia. 

Acute Pain Models:

• Tail flick test (Radiant heat or warm water tail immersion)
• Plantar test (Hargreaves’ method) using radiant heat stimulus
• Hot-plate test (paw withdrawal)
• Formalin test (Phase I an II response(s))
• Orofacial formalin test

Chronic Pain Models:

• Chronic constriction injury ―CCI, Bennett Model*
• Spinal nerve ligations ―SNL, Chung Model*
• Streptozotocin (STZ) induced diabetic neuropathy*

Inflammatory Models:

• Complete Freund's adjuvant (CFA) injections to the hind paw*
• Carrageenan injections to the hind paw*

* Radiant heat stimulus (Hargreaves’ method) is used to measure thermal hyperalgesia, and/or von Frey Test is used to measure mechanical allodynia.

Compound delivery include:  Intrathecal catheter (Yaksh's method), kidney capsule, intravenous, oral, subcutaneous, intradermal, intranasal, patch implant, Alzet and/or external pump placement.  Please ask if you need a custom design method of delivery.

Contact SRI Biosciences

       Last Updated Mar 19, 2009