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Sleep and Circadian Rhythm Research Services

SRI has a dedicated Sleep and Circadian Rhythm Facility for animal studies. Two light- and temperature-controlled experimental rooms used for recording rodents in long-term experiments flank a central procedure room where neurochemicals are prepared for injection and perfusions and dissections are performed. Data collection is continuously monitored from an adjacent data analysis room. A surgery suite is also adjacent to the recording rooms. Specialized equipment includes

• ClockLab circadian data collection and analysis system
• E-mitter system for measurement of activity and body temperature by inductive telemetry
• Embla digital EEG/EMG recording system for sleep studies
• Grass Instruments polygraphs
• Photobeam activity monitoring system.

Scope of Services

SRI's Sleep and Circadian Rhythm Facility can evaluate investigational drugs or induced mutant animals for effects on activity, body temperature, sleep/wakefulness and arousal. Study capabilities include

• Sleep/wake recordings and analysis
• Quantified electroencephalogram (EEG) recording
• Electromyogram (EMG) recording
• Core body temperature recording (by telemetry)
• Circadian rhythms, indicated by
  • Running wheel activity
  • Photobeam activity monitoring
  • Core body temperature rhythms

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       Last Updated Mar 19, 2009