SRI Shenandoah Valley was established in Harrisonburg, Virginia in 2006 to foster economic development centered on research and technology. The new facility received support from the Commonwealth of Virginia and partnerships with James Madison University, Rockingham County, the City of Harrisonburg, the Virginia Economic Development Partnership, and the Shenandoah Valley Partnership. Stakeholders include the education sector, business and industry, economic development advocates, workforce development groups, community organizations, and local government.

The state-of-the-art 40,000-square-foot research facility is located on a 25-acre campus in the Rockingham Center for Research and Technology. With this presence in Harrisonburg, the SRI facility provides a convenient base for collaboration with academic institutions in Virginia and the greater Washington, D.C. area.

Watch video of the facility's dedication in 2009.

SRI opened the Center for Advanced Drug Research (CADRE) at the Shenandoah Valley facility in 2009. CADRE focuses on improving the productivity of the pharmaceutical industry, helping our nation respond to biothreats, and developing life-saving treatments for neglected and orphan diseases. As part of SRI Biosciences, CADRE complements pharmaceutical capabilities at SRI's Menlo Park, California headquarters.

Over time, SRI Shenandoah Valley plans to add high-technology programs in other areas, such as security and defense, microscience, energy, and computing technology. As SRI Shenandoah Valley conducts cutting-edge research on globally important problems, it is expected to serve as a magnet for student intern training, and for faculty to spend their sabbaticals actively engaged in R&D with real-world applications. SRI's collaborations with leading Virginia academic institutions are facilitated by government funding, sponsored industrial research, and private foundation support.

In July 2011, SRI announced plans to expand ts Shenandoah Valley facility.