Selected Publications (2000-2005)

NHLBI Twin Studies

Carmelli D, DeCarli C, Swan GE, Kelly-Hayes M, Wolf PA, Reed T and Guralnik JM. The joint effect of apolipoprotein E epsilon4 and MRI findings on lower-extremity function and decline in cognitive function. J Gerontol A Biol Sci Med Sci. 2000;55(2):M103-9.

Carmelli D, Fabsitz RR, Swan GE, Reed T, Miller B and Wolf PA. Contribution of genetic and environmental influences to ankle-brachial blood pressure index in the NHLBI Twin Study. National Heart, Lung, and Blood Institute. Am J Epidemiol. 2000;151(5):452-8.

Pfefferbaum A, Sullivan EV, Swan GE and Carmelli D. Brain structure in men remains highly heritable in the seventh and eighth decades of life. Neurobiol Aging. 2000;21(1):63-74.

Reed T, Kirkwood SC, DeCarli C, Swan GE, Miller BL, Wolf PA, Jack LM and Carmelli D. Relationship of family history scores for stroke and hypertension to quantitative measures of white-matter hyperintensities and stroke volume in elderly males. Neuroepidemiology. 2000;19(2):76-86.

Reed T, Carmelli D, Swan GE, Wolf PA, Miller BL, Krasnow R and Smith WM. Ten-year follow-up for male twins divided into high- or low-risk groups for ischemic heart disease based on risk factors measured 25 years previously. Ann Epidemiol. 2000;10(5):278-84.

Swan GE, DeCarli C, Miller BL, Reed T, Wolf PA and Carmelli D. Biobehavioral characteristics of nondemented older adults with subclinical brain atrophy. Neurology. 2000;54(11):2108-14.

Carmelli D, Bliwise DL, Swan GE and Reed T. Genetic factors in self-reported snoring and excessive daytime sleepiness: a twin study. Am J Respir Crit Care Med. Sep 15 2001;164(6):949-52.

DeCarli C, Miller BL, Swan GE, Reed T, Wolf PA and Carmelli D. Cerebrovascular and brain morphologic correlates of mild cognitive impairment in the National Heart, Lung, and Blood Institute Twin Study. Arch Neurol. 2001;58(4):643-7.

Pfefferbaum A, Sullivan EV and Carmelli D. Genetic regulation of regional microstructure of the corpus callosum in late life. Neuroreport. 2001;12(8):1677-81.

Sullivan EV, Pfefferbaum A, Swan GE and Carmelli D. Heritability of hippocampal size in elderly twin men: equivalent influence from genes and environment. Hippocampus. 2001;11(6):754-62.

Carmelli D, Reed T and DeCarli C. A bivariate genetic analysis of cerebral white matter hyperintensities and cognitive performance in elderly male twins. Neurobiol Aging. 2002;23(3):413-20.

Carmelli D, Swan GE, DeCarli C and Reed T. Quantitative genetic modeling of regional brain volumes and cognitive performance in older male twins. Biol Psychol. 2002;61(1-2):139-55.

Geschwind DH, Miller BL, DeCarli C and Carmelli D. Heritability of lobar brain volumes in twins supports genetic models of cerebral laterality and handedness. Proc Natl Acad Sci U S A. 2002;99(5):3176-81.

Sullivan EV, Pfefferbaum A, Adalsteinsson E, Swan GE and Carmelli D. Differential rates of regional brain change in callosal and ventricular size: a 4-year longitudinal MRI study of elderly men. Cerebral Cortex. 2002;12(4):438-45.

Swan GE and Carmelli D. Evidence for genetic mediation of executive control: a study of aging male twins. J Gerontol B Psychol Sci Soc Sci. 2002;57(2):P133-43.

Reed T, Carmelli D, Robinson TS, Rinehart SA and Williams CJ. More favorable midlife cardiovascular risk factor levels in male twins and mortality after 25 years of follow-up is related to longevity of their parents. J Gerontol A Biol Sci Med Sci. 2003;58(4):367-71

Mikulec KH, Holloway L, Krasnow RE, Javitz H, Swan GE, Reed T, Marcus R and Carmelli D. Relationship of endogenous sex hormones to coronary heart disease: a twin study. J Clin Endocrinol Met 2004;89(3):1240-5.

Pfefferbaum A, Sullivan EV and Carmelli D. Morphological changes in aging brain structures are differentially affected by time-linked environmental influences despite strong genetic stability. Neurobiol Aging 2004;25(2):175-83.

Ring HZ, Lessov CN, Reed T, Marcus R, Holloway L, Swan GE, Carmelli D. Heritability of Plasma Sex Hormones and Hormone Binding Globulin in Adult Male Twins. J Clin Endocrinol Met 2005;90(6):3653-8

Lessov-Schlaggar CN, Reed T, Swan GE, Krasnow RE, DeCarli C, Marcus R, Holloway L, Wolf PA, Carmelli D. Association of sex hormones with brain morphology and cognition in healthy elderly men. Neurology 2005;in press

Western Collaborative Group Study

Carmelli, D., Swan, G. E., & Bliwise, D. L. The relationship of 30-year changes in obesity to sleep-disordered breathing in the Western Collaborative Group Study. Obesity Res. 2000;8: 632-637.

Cheng, L. S.-C., Carmelli, D., Swan, G. E., & Pfefferbaum, A. Segregation analysis of excessive alcohol consumption in elderly men and their first-degree relatives from the Western Collaborative Group Study. Annals Epidemiol 2000;10:309-315.

Cheng, L. S.-C., Swan, G. E., & Carmelli, D. A genetic analysis of smoking behavior in family members of older adult males. Addiction 2000;95;427-435.

Swan, G. E., Carmelli, D. Impaired olfaction predicts cognitive decline in nondemented older adults. Neuroepidemiol 2002;21:58-67.

Eslinger, P.J., Swan, G.E., & Carmelli, D. Changes in Mini-Mental State Exam in community-dwelling older persons over 6 years: relationship to health and neuropsychological measures.  Neuroepidemiol 2003;22(1):23-30.

Swan GE, Lessov-Schlaggar CN, Carmelli D, Schellenberg GD, LaRue A. Apolipoprotein E e4 and 5-year change in neurobehavioral functioning in nondemented, community-dwelling older men and women. J Geriatric Psychiatry Neurol 2005;in press

Tobacco Use

Cheng LS, Swan GE, Carmelli D. A genetic analysis of smoking behavior in family members of older adult males. Addiction 2000;95(3):427-35.

Li MD, Cheng R, Ma JZ, Swan GE. A meta-analysis of estimated genetic and environmental effects on smoking behavior in male and female adult twins. Addiction 2003;98(1):23-31.

Hudmon KS, Marks JL, Pomerleau CS, Bolt DM, Brigham J, Swan GE. A multidimensional model for characterizing tobacco dependence. Nicotine Tob Res 2003;5(5):655-64.

Swan GE, Hudmon KS, Jack LM, Hemberger K, Carmelli D, Khroyan TV, Ring HZ, Hops H, Andrews JA, Tildesley E, McBride D, Benowitz N, Webster C, Wilhelmsen KC, Feiler HS, Koenig B, Caron L, Illes J, Cheng LS Environmental and genetic determinants of tobacco use: methodology for a multidisciplinary, longitudinal family-based investigation. Cancer Epidemiol Biomarkers Prev 2003;12(10):994-1005

McCaffery JM, Niaura R, Swan GE, Carmelli D. A study of depressive symptoms and smoking behavior in adult male twins from the NHLBI twin study. Nicotine Tob Res 2003;5(1):77-83.

Swan GE, Benowitz NL, Jacob P, III, Lessov CN, Tyndale RF, Wilhelmsen K, Krasnow RE, McElroy M, Moore S, Wambach M Pharmacogenetic investigation of nicotine metabolism: Measurement of pharmacokinetic phenotypes in twins. Twin Research 2004;7:435-48

Lessov CN, Swan GE, Ring HZ, Khroyan TV, Lerman C. Genetics and prevention of drug abuse: Implications for transdisciplinary research and practice. Substance Use Misuse 2004;39:1515-69

Swan GE, Lessov CN. Gene-environment interactions in nicotine addiction: the need for a large-scale, collaborative effort. Substance Use Misuse 2004;39:2083-85

Swan GE, Benowitz NL, Lessov CN, Jacob P, III, Tyndale RF, Wilhelmsen K. Nicotine metabolism: The impact of CYP2A6 on estimates of additive genetic influence. Pharmacogenet Genom 2005;15(2):115-25

Wilhelmsen KC, Swan GE, Cheng LS-C, Lessov CN, Amos C, Feiler HS, Hudmon KS, Ring HZ, Andrews JA, Tildesley E, Benowitz N, Hops H. Support for previously identified alcoholism susceptibility loci in a cohort selected for smoking behavior. Alcohol Clin Exp Res 2005; in press