| |
 Publications by study
Pharmacokinetics of Nicotine in Twins
Sponsor: National Institute on Drug Abuse
Project Dates: 03/05/1998—02/28/2005
Principal Investigator: Gary E. Swan, Ph.D., Director, Center for Health Sciences, SRI International
| 1. |
Swan, G. E., Carmelli, D., Benowitz, N., Jacob, P.
Pharmacokinetics of nicotine in twins.
Abstract presented to the 6th annual meeting of the Society for Research in Nicotine and Tobacco, Seattle, March 23-25, 2000. |
| 2. |
Wu, X., Spitz, M.R., de Andrade, M., Benowitz, N. L.; Swan, G.E.
Genetic Influence on Mutagen Sensitivity: A Twin Study.
Proceedings of the American Association for Cancer Research 41:437, 2000.
|
| 3. |
Swan, G. E., Benowitz, N. L., Carmelli, D., Jacob, P., Karan, L.
Genetic influences on heart rate responsiveness to nicotine infusion.
Abstract presented to the 8th annual meeting of the Society for Research in Nicotine and Tobacco, Savannah, GA, February 20-23, 2002. Abstract published in Nicotine & Tobacco Research, 2002, 4, 364-365. |
| 4. |
Benowitz, N. L., Tyndale, R., Jacob, P., Swan, G. E.
CYP2A6 polymorphism and nicotine metabolism.
Abstract presented to the annual meeting of the American Society of Clinical Pharmacology, Atlanta, GA, March 24-27, 2002. |
| 5. |
Wu, X., Amos, C. I., Zhu, Y., Zhao, H., Grossman, B. H., Shay, J. W., Swan, G. E., Benowitz, N. L., Luo, S., Spitz, M. R.
Heritability of telomere length and its role in cancer predisposition.
American Association for Cancer Research, San Francisco, 2002. |
| 6. |
Swan, G. E., Benowitz, N. L., Jacob III, P., Lessov, C. N., Tyndale, R. F., Wilhelmsen, K., Krasnow, R. E., McElroy, M. R., Moore, S. E., Wambach, M.
Pharmacogenetics of nicotine metabolism in twins: Methods and procedures.
Twin Research, 2004, 7, 435-448. |
| 7. |
Ring, H. Z., Valdez, A. M., Katsuyoshi, D., Jacob, III, P., Walton, R., Swan, G. E., Benowitz, N. L.
CYP2B6 and CYP2A6 polymorphisms: Gene-gene interaction and nicotine metabolism.
Abstract presented to the 54th annual meeting of the American Society of Human Genetics, Toronto, Canada, October 2004. |
| 8. |
Ring, H. Z., Valdez, A. M., Katsuyoshi, D., Jacob, III, P., Swan, G. E., Benowitz, N. L.
UDP-glucuronosyltransferase 2B7 genotype and nicotine glucuronidation.
Abstract presented to the 54th annual meeting of the American Society of Human Genetics, Toronto, Canada, October 2004. |
| 9. |
Munafo, R. M., Lerman, C., Niaura, R., Shields, A. E., Swan, G. E.
Smoking cessation treatment: Pharmacogenetic assessment.
Current Opinion in Molecular Therapeutics, 2005, 7, 202-208. |
| 10. |
Swan, G. E., Benowitz, N. L., Lessov, C. N., Jacob III, P., Tyndale, R. F., Wilhelmsen, K.
Nicotine metabolism: The impact of CYP2A6 on estimates of additive genetic influence.
Pharmacogenetics and Genomics, 2005, 15, 115-125. |
| 11. |
Krasnow, R. E., McElroy, M. R., Swan, G. E., Benowitz, N. L.
Subjective reactions to two methods of nicotine administration.
Abstract presented to the 12th annual meeting of the Society for Research on Nicotine and Tobacco, Orlando, FL, February 2006. |
| 12. |
Benowitz, N. L., Lessov-Schlaggar, C. N., Swan, G. E., Jacob III, P.
Female sex and oral contraceptive use accelerate nicotine metabolism.
Clinical Pharmacology and Therapeutics, 2006, 79, 480-488. |
| 13. |
Al Koudsi, N., Mwenifumbo, J. C., Sellers, E. M., Benowitz, N. L., Swan, G. E., Tyndale, R. F.
Characterization of the novel CYP2A6*21 allele using in vivo nicotine kinetics.
European Journal of Clinical Pharmacology, 2006, 62, 481-484. |
| 14. |
Wu, X., Spitz, M. R., Amos, C. I., Lin, J., Shao, L., Gu, J., de Andrade, M., Benowitz, N. L., Shields, P. G., Swan, G. E.
Mutagen sensitivity has high heritability: Evidence from a twin study.
Cancer Research, 2006, 66, 5993-5996. |
| 15. |
Benowitz, N. L., Swan, G. E., Jacob, P. 3rd, Lessov-Schlaggar, C. N., Tyndale, R. F.
CYP2A6 genotype and the metabolism and disposition kinetics of nicotine.
Clinical Pharmacology and Therapeutics, 2006, 80, 457-467. |
| 16. |
Lin, J., Swan, G. E., Shields, P. G., Benowitz, N. L., Gu, J., Amos, C. I., de Andrade, M., Spitz, M. R., Wu, X.
Benzo[a]pyrene diol epoxide induced chromatid breaks in peripheral blood lymphocytes are modified by nucleotide excision repair pathway genes. Paper submitted. |
| 17. |
Swan, G. E., Lessov-Schlaggar, C. N., Krasnow, R. E., Jacob III, P. Benowitz, N. L.
Genetic and environmental sources of variation in heart rate response to infused nicotine in twins.
Cancer Epidemiology Biomarkers and Prevention, 2007, 16, 1057-64. |
| 18. |
Mwenifumbo, J. C., Lessov-Schlaggar, C. N., Zhou, Q., Krasnow, R. E., Swan, G. E., Benowitz, N. L., Tyndale, R. F.
Identification of Novel CYP2A6*1B Variants: The CYP2A6*1B Allele is Associated With Faster In Vivo Nicotine Metabolism.
Clin Pharmacol Ther, 2007, May 23; [Epub ahead of print]. |
| 19. |
Benowitz, N. L., Lessov-Schlaggar, C. N., Swan, G. E.
Heritability of nicotine and cotinine renal clearance.
Pharmcogenetics and Genomics, Manuscript under revision. |
| 20. |
Swan, G. E., Lessov-Schlaggar, C. N., Benowitz, N. L..
Bivariate genetic analysis of heart rate response to nicotine and nicotine metabolism. Manuscript in preparation. |
| 21. |
Swan, G. E., et al.
CYP2A6 and CYP2B6 interaction and its effect on estimates of additive genetic variance in nicotine metabolism. Analyses underway. |
| 22. |
Lessov-Schlaggar, C. N., Benowitz, N. L., Swan, G. E.
Genetic analysis of glucuronide clearance in slow nicotine metabolizers. Analyses underway. |
| 23. |
Swan G. E., et al.
Genomewide linkage analysis of nicotine metabolism. Manuscript in preparation. |
Contact Us
Center for Health Sciences
SRI International
333
Ravenswood Avenue
Menlo Park, CA 94025
SRITWIN@sri.com
Phone:
1-800-SRI-TWIN (1-800-774-8946)
Fax: 650-859-5099
|
|
R&D Divisions