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Publications by study
- Pharmacokinetics of nicotine in twins
- Development of facial identification technology
- Investigation of the role of genetics in response to cancer-causing agents
- Examination of the extent to which genetics and environment affect sleep in children
- Comparison of the pharmacokinetics of the medication digoxin (a heart regulator) in identical and fraternal twins to determine whether inter-individual variability is due to genetic factors
- Examination of the renal clearance of the commonly used prescription medication metformin (used in treatment of diabetes) in identical and fraternal twins to determine the role of heredity
Pharmacokinetics of Nicotine in Twins
Sponsor: National Institute on Drug Abuse
Project Dates: 03/05/1998—02/28/2005
Principal Investigator: Gary E. Swan, Ph.D., Director, Center for Health Sciences, SRI International
| 1. |
Swan, G. E., Carmelli, D., Benowitz, N., Jacob, P.
Pharmacokinetics of nicotine in twins.
Abstract presented to the 6th annual meeting of the Society for Research in Nicotine and Tobacco, Seattle, March 23-25, 2000. |
| 2. |
Wu, X., Spitz, M.R., de Andrade, M., Benowitz, N. L.; Swan, G.E.
Genetic Influence on Mutagen Sensitivity: A Twin Study.
Proceedings of the American Association for Cancer Research 41:437, 2000. |
| 3. |
Swan, G. E., Benowitz, N. L., Carmelli, D., Jacob, P., Karan, L.
Genetic influences on heart rate responsiveness to nicotine infusion.
Abstract presented to the 8th annual meeting of the Society for Research in Nicotine and Tobacco, Savannah, GA, February 20-23, 2002. Abstract published in Nicotine & Tobacco Research, 2002, 4, 364-365. |
| 4. |
Benowitz, N. L., Tyndale, R., Jacob, P., Swan, G. E.
CYP2A6 polymorphism and nicotine metabolism.
Abstract presented to the annual meeting of the American Society of Clinical Pharmacology, Atlanta, GA, March 24-27, 2002. |
| 5. |
Wu, X., Amos, C. I., Zhu, Y., Zhao, H., Grossman, B. H., Shay, J. W., Swan, G. E., Benowitz, N. L., Luo, S., Spitz, M. R.
Heritability of telomere length and its role in cancer predisposition.
American Association for Cancer Research, San Francisco, 2002. |
| 6. |
Swan, G. E., Benowitz, N. L., Jacob III, P., Lessov, C. N., Tyndale, R. F., Wilhelmsen, K., Krasnow, R. E., McElroy, M. R., Moore, S. E., Wambach, M.
Pharmacogenetics of nicotine metabolism in twins: Methods and procedures.
Twin Research, 2004, 7, 435-448. |
| 7. |
Ring, H. Z., Valdez, A. M., Katsuyoshi, D., Jacob, III, P., Walton, R., Swan, G. E., Benowitz, N. L.
CYP2B6 and CYP2A6 polymorphisms: Gene-gene interaction and nicotine metabolism.
Abstract presented to the 54th annual meeting of the American Society of Human Genetics, Toronto, Canada, October 2004. |
| 8. |
Ring, H. Z., Valdez, A. M., Katsuyoshi, D., Jacob, III, P., Swan, G. E., Benowitz, N. L.
UDP-glucuronosyltransferase 2B7 genotype and nicotine glucuronidation.
Abstract presented to the 54th annual meeting of the American Society of Human Genetics, Toronto, Canada, October 2004. |
| 9. |
Munafo, R. M., Lerman, C., Niaura, R., Shields, A. E., Swan, G. E.
Smoking cessation treatment: Pharmacogenetic assessment.
Current Opinion in Molecular Therapeutics, 2005, 7, 202-208. |
| 10. |
Swan, G. E., Benowitz, N. L., Lessov, C. N., Jacob III, P., Tyndale, R. F., Wilhelmsen, K.
Nicotine metabolism: The impact of CYP2A6 on estimates of additive genetic influence.
Pharmacogenetics and Genomics, 2005, 15, 115-125. |
| 11. |
Krasnow, R. E., McElroy, M. R., Swan, G. E., Benowitz, N. L.
Subjective reactions to two methods of nicotine administration.
Abstract presented to the 12th annual meeting of the Society for Research on Nicotine and Tobacco, Orlando, FL, February 2006. |
| 12. |
Benowitz, N. L., Lessov-Schlaggar, C. N., Swan, G. E., Jacob III, P.
Female sex and oral contraceptive use accelerate nicotine metabolism.
Clinical Pharmacology and Therapeutics, 2006, 79, 480-488. |
| 13. |
Al Koudsi, N., Mwenifumbo, J. C., Sellers, E. M., Benowitz, N. L., Swan, G. E., Tyndale, R. F.
Characterization of the novel CYP2A6*21 allele using in vivo nicotine kinetics.
European Journal of Clinical Pharmacology, 2006, 62, 481-484. |
| 14. |
Wu, X., Spitz, M. R., Amos, C. I., Lin, J., Shao, L., Gu, J., de Andrade, M., Benowitz, N. L., Shields, P. G., Swan, G. E.
Mutagen sensitivity has high heritability: Evidence from a twin study.
Cancer Research, 2006, 66, 5993-5996. |
| 15. |
Benowitz, N. L., Swan, G. E., Jacob, P. 3rd, Lessov-Schlaggar, C. N., Tyndale, R. F.
CYP2A6 genotype and the metabolism and disposition kinetics of nicotine.
Clinical Pharmacology and Therapeutics, 2006, 80, 457-467. |
| 16. |
Lin, J., Swan, G. E., Shields, P. G., Benowitz, N. L., Gu, J., Amos, C. I., de Andrade, M., Spitz, M. R., Wu, X.
Benzo[a]pyrene diol epoxide induced chromatid breaks in peripheral blood lymphocytes are modified by nucleotide excision repair pathway genes. Paper submitted. |
| 17. |
Swan, G. E., Lessov-Schlaggar, C. N., Krasnow, R. E., Jacob III, P. Benowitz, N. L.
Genetic and environmental sources of variation in heart rate response to infused nicotine in twins.
Cancer Epidemiology Biomarkers and Prevention, 2007, 16, 1057-64. |
| 18. |
Mwenifumbo, J. C., Lessov-Schlaggar, C. N., Zhou, Q., Krasnow, R. E., Swan, G. E., Benowitz, N. L., Tyndale, R. F.
Identification of Novel CYP2A6*1B Variants: The CYP2A6*1B Allele is Associated With Faster In Vivo Nicotine Metabolism.
Clin Pharmacol Ther, 2007, May 23; [Epub ahead of print]. |
| 19. |
Benowitz, N. L., Lessov-Schlaggar, C. N., Swan, G. E.
Heritability of nicotine and cotinine renal clearance.
Pharmcogenetics and Genomics, Manuscript under revision. |
| 20. |
Swan, G. E., Lessov-Schlaggar, C. N., Benowitz, N. L..
Bivariate genetic analysis of heart rate response to nicotine and nicotine metabolism. Manuscript in preparation. |
| 21. |
Swan, G. E., et al.
CYP2A6 and CYP2B6 interaction and its effect on estimates of additive genetic variance in nicotine metabolism. Analyses underway. |
| 22. |
Lessov-Schlaggar, C. N., Benowitz, N. L., Swan, G. E.
Genetic analysis of glucuronide clearance in slow nicotine metabolizers. Analyses underway. |
| 23. |
Swan G. E., et al.
Genomewide linkage analysis of nicotine metabolism. Manuscript in preparation. |
| 24. |
McClure, J. B., Swan, G. E., Catz, S. L., Jack, L., Javitz, H., McAfee, T., Deprey, M., Richards, J., Zbikowski, S. M. Smoking outcome by psychiatric history after behavioral and varenicline treatment. Journal of Substance Abuse Treatment, in press. |
| 25. |
Conway, K. P., Levy, J., Vanyukov, M., Chandler, R., Rutter, J., Swan, G. E., Neale, M. Measuring addiction propensity and severity: The need for a new instrument. Drug and Alcohol Dependence, in press. |
| 26. |
Swan, G. E., McClure J. B., Jack, L. M., Zbikowski, S. M., Javitz, H., Catz, S. L., Deprey, M., Richards, J., McAfee, T. A. Behavioral counseling and varenciline treatment for smoking cessation: Results from a randomized effectiveness trial. American Journal of Preventive Medicine, in press. |
Contact Us
Center for Health Sciences
SRI International
333
Ravenswood Avenue
Menlo Park, CA 94025
SRITWIN@sri.com
Phone:
1-800-SRI-TWIN (1-800-774-8946)
Fax: 650-859-5099
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R&D Divisions