Drug Metabolism and Pharmacokinetics

SRI offers comprehensive drug metabolism and pharmacokinetic (DMPK) services to meet your needs. We give you access to a complete range of capabilities, beginning with dose administration followed by full-service bioanalytical support and pharmacokinetic data analysis and interpretation. We offer PK studies that fully comply with U.S. FDA GLP regulations.

Related Services

Bioanalytical Quantitative Methods

  • Bioanalytical method development and validation

    • Small molecules: LC/MS/MS, GC-MS, HPLC with UV,
      fluorescence, radiochemical detection

    • Proteins: ELISA, antibody titer

  • Quantitative PCR

    • DNA/RNA test article, e.g., plasmid, virus

    • Biodistribution, persistence, integration

    • mRNA expression levels

    • Subcellular localization

    • Chromosomal integration

Pharmacokinetic and Pharmacodynamic
Analyses

  • Single-dose pharmacokinetics

  • Bioavailability

  • Multiple-dose pharmacokinetics

  • Drug accumulation

  • Metabolite identification

  • WinNonlin™ compartmental and noncompartmental analysis

  • PK/PD interpretation

  • Bioequivalence

  • Allometric estimations

  • Formulation screening

Comprehensive ADME

  • Absorption and clearance

  • Tissue distribution

  • DNA/RNA biodistribution, persistence, integration

  • Interspecies comparative metabolism

  • Metabolite profile

  • Excretion and mass balance

  • Radiolabeled drug synthesis

 

Projects

scientist looking through a microscope
Toxicological Evaluation of Novel Ligands Program

For the National Institute of Mental Health (NIMH), SRI performs preclinical safety and pharmacokinetics studies for brain imaging agents and drugs to treat mental illnesses.

Topics: Developmental + Reproductive Toxicology Discovery ADMET and In Vitro Metabolism Drug Metabolism and Pharmacokinetics Genetic Toxicology Pharmaceutical R+D Safety Pharmacology Toxicology and Safety

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