Medicinal Chemistry

The identification, synthesis, and development of drugs for therapeutic use requires medicinal chemistry. For commercial and government clients, SRI Biosciences chemists perform complex and multistep drug synthesis procedures using expertise in radiochemistry services, chiral synthesis, bioisostere incorporation, process design, and process optimization.

SRI researchers operate in modern laboratories equipped with computer-assisted drug design instrumentation and parallel synthesis equipment. Services include:

• Custom drug synthesis, featuring ideal, timely, and cost-effective outsourcing options

• Custom isotope labeling, for isotopically labeled compounds of high purity and high isotopic enrichment. SRI offers specific labeling patterns for complex molecules and drugs used in metabolism and biochemical studies.

• Parallel synthesis, for the design and synthesis of small molecule, peptide, and peptidomimetic libraries using both solution and solid-phase synthesis approaches. SRI works with clients to generate moderate-sized focused libraries.

Complex targets we have synthesized include

• Artemesin antimalarials

• Benzotriazine anticancer agents

• Carbapenem antibiotics

• Steroidal HRT and anticancer agents

• Peptidomimetic antihypertensives

• Catechin chemopreventives

• Methotrexate anticancer agents