Neuroscience

The study of the nervous system's molecular, cellular, developmental, and functional aspects comprises neuroscience research, and is key to understanding the many facets of human sleep, pain, and addiction.

Researchers in SRI’s Center for Health Sciences Neuroscience Program conduct extensive research using biochemistry, molecular biology, proteomics, electrophysiology, and behavioral testing techniques. They also study the brain's structure and function using magnetic resonance imaging technology.

SRI's Center for Neuroscience combines world-class basic science with contract research to provide an environment ideal to partner with clients and help advance research and development programs. We conduct basic research in sleep, circadian rhythms, pain, and addiction using techniques in biochemistry, molecular biology, proteomics, electrophysiology, and behavioral testing.

Projects

twin boys

SRI established the Twin Research Registry as part of its scientific research and efforts to discover more about human behavior. Fraternal and identical twins and multiples of all ages are invited to join the Registry for consideration for research studies.

nicotinic receptors affect brain activity

To support more effective cessation treatments, SRI researchers are exploring how nicotinic receptors affect brain activity in response to smoking.

cigarette being snapped in half

SRI is analyzing the genetics of smoking and related characteristics, using data from a large-scale National Cancer Institute study on smoking cessation.

diagram of nicotinic receptors

SRI is investigating whether the nicotine in tobacco smoke may be useful in meeting the urgent need to manage Parkinson’s disease.

scientist working at a computer

SRI is investigating novel methods and treatments to improve cognitive deficits caused by diseases such as Alzheimer’s and depression.

group of teens sitting together on the grass

SRI’s Sleep Research Laboratory in Menlo Park, California is currently recruiting for this study.

Press Releases

brain scan

SRI neuroscientists have found that a form of baclofen, a drug used to treat muscle spasticity, works better at treating narcolepsy than the best drug currently available when tested in mice.

Findings point to a biochemical and physiological explanation of how sleep need, which gradually builds up during wakefulness, is dissipated during sleep.

illustration of the human brain

Researchers have demonstrated that measurements of electrical activity in models of Huntington’s disease could indicate the presence of disease before the onset of major symptoms. Further research on potential biomarkers might one day enable tracking of disease progression.

image of a mouse brain

SRI neuroscience researchers will use Inscopix’s nVista HD imaging system to gain a better understanding of normal brain function and the dysfunctions of neural circuitry that underlie neurological and neuropsychiatric disorders.

Joseph Rogers

In his career, Rogers has focused on age-related neurologic diseases. He is best known for showing that inflammatory responses occur in almost all major age-related brain disorders and cause substantial damage, with his seminal paper in the area receiving nearly 1,200 citations to date.

Adolf Pfefferbaum

The Research Society on Alcoholism (RSA) awarded its 2011 Distinguished Researcher Award to Adolf Pfefferbaum, M.D., director of the Neuroscience Program in the Center for Health Sciences at SRI International and a professor at Stanford University School of Medicine.

Gary Swang, director of SRI International's Center for Health Sciences

Gary E. Swan, Ph.D., director of SRI International's Center for Health Sciences, has been elected by the membership of the Society for Research on Nicotine and Tobacco (SRNT) as its president-elect and will serve as president in 2012.

SRI International, an independent nonprofit research and development institute, announced today that a new Neurodegenerative Diseases Research Program has been established within its Center for Health Sciences.

SRI International, an independent nonprofit research and development institute, announced today that Thomas S. Kilduff, Ph.D., director of SRI International's Center for Neuroscience, has been named a Fellow of the American Association for the Advancement of Science (AAAS).

SRI International, an independent nonprofit research and development organization, announced today that its Center for Neuroscience has entered into a research collaboration with F. Hoffmann-La Roche.

Topics: Neuroscience

SRI In the News

brain scan image
Narcolepsy: Sleepy Days, Not Nights

SRI researchers think they may have stumbled onto a way to refine a drug that can treat narcolepsy more effectively, and it has been around for 50 years.

Events

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SRI Biosciences will exhibit.

Topics: Neuroscience

Publications

Researchers conclude that cortical nNOS neurons and nNOS enzymatic activity are likely involved in the homeostatic regulation of slow wave sleep.

The Twin Research Registry at SRI International is a community-based registry of twins established in 1995. As of August 2012, there are 3,120 same- and opposite-sex twins enrolled.