Projects

Biomedical Sciences + Health

Anti-Angiogenic Molecule Treatment for Multiple Myeloma

SRI has developed a promising new treatment for this cancer of the immune system that affects plasma cells in bone marrow.

Anti-Infectives Development for National Institutes of Health

SRI is conducting preclinical development of treatments for diseases such as tuberculosis, West Nile virus, hepatitis, and biodefense pathogens and toxins.

BioCyc Database Collection

A comprehensive website for sharing fundamental information about biochemical pathways and genomes with researchers around the world.

Biodosimeter to Triage Exposure to Ionizing Radiation

In a nuclear or radiological incident, first responders must quickly measure the radiation exposure of a large number of individuals, since treatment options are radiation dose-dependent and time-sensitive. SRI is developing a biodosimeter to meet this critical challenge.

Bis-Indole Drug Discovery in Multiple Therapeutic Areas

SRI is identifying candidates for advanced therapies in multiple disease areas by developing compounds from synthetically optimized, natural dietary products.

Brain Changes Associated with Sleep Deprivation

Lack of sleep can lead to a range of cognitive, attention, and emotional deficits. SRI and its partner have made a thorough study of its effects on the brain.

Discovery of Tyrosine Kinase 2 Inhibitors

Novel molecular targets of several cytokines are being evaluated by SRI scientists, with the goal of designing a small-molecule drug to block responses involved in many of these inflammatory diseases.

Early Detection Tool for Neglected Tropical Diseases

SRI is developing a novel point-of-care tool for the early detection of devastating diseases.

EcoCyc: Encyclopedia of E. coli Genes and Metabolism

EcoCyc is SRI's bioinformatics database that describes the genome and the biochemical machinery of Escherichia coli.

Gyrase B Inhibitors for Tuberculosis

SRI is seeking new treatments for tuberculosis, a global health crisis.

Hypocretin Agonists as Treatments for Narcolepsy + Wakefulness

SRI sleep researchers are working to discover and develop new treatments for narcoleptic patients.

Improving Cognitive Deficits

SRI is investigating novel methods and treatments to improve cognitive deficits caused by diseases such as Alzheimer’s and depression.

MISTRAL Pediatric Device Consortium

To address a critical healthcare need, SRI is partnering to develop medical devices for treating children.

Needle-Free Transmucosal Drug Delivery System

SRI has patented a novel approach to vaccine delivery that is safe for pediatric use, eliminating the need for painful injections.

Oral Formulation of DTPA to Counter Radiation Exposure

A new oral version of a known chelating agent can defend against mass radiation exposure in a terrorist attack.

Quadri: Intelligent Question Answering in the HIV Domain

SRI, Stanford University, and PARC co-developed an intelligent system for answering English questions about HIV treatment.

Real-Time Tomosynthesis + Stationary X-Ray Source

SRI is developing technologies that could significantly improve tomographic medical imaging for cancer treatment and research.

Role of Alpha6 Nicotinic Receptors in Smoking

To support more effective cessation treatments, SRI researchers are exploring how nicotinic receptors affect brain activity in response to smoking.

Role of Nicotinic Receptors in Parkinson’s Disease

SRI is investigating whether the nicotine in tobacco smoke may be useful in meeting the urgent need to manage Parkinson’s disease.

Salivary Biomarkers, Life Stress + Nicotine Dependence

Predicting individuals' vulnerability to nicotine dependence could identify factors in genes and the environment that help to explain the success or failure of attempts to prevent tobacco use and addiction.

Sleep and Reproductive Transitions in Menopausal Women

Sleep complaints are common during the transition to menopause, yet we have little understanding of what drives this increase in sleep disturbance and how best to treat it. SRI researchers are investigating sleep quality in women who have begun to go through menopause.

SMARTT Projects: Treatments for Lung, Heart, Blood Diseases

Through a broad range of services for the National Institutes of Health, SRI is accelerating preclinical development of potential therapies for diseases that affect millions of people.

Toxicological Evaluation of Novel Ligands Program

For the National Institute of Mental Health (NIMH), SRI performs preclinical safety and pharmacokinetics studies for brain imaging agents and drugs to treat mental illnesses.

Treatment of Nicotine Dependence in a Healthcare Setting

SRI is analyzing the genetics of smoking and related characteristics, using data from a large-scale National Cancer Institute study on smoking cessation.

Twin Research Registry at SRI International

SRI established the Twin Research Registry as part of its scientific research and efforts to discover more about human behavior. Fraternal and identical twins and multiples of all ages are invited to join the Registry for consideration for research studies.

Using Twins to Understand Opioid Efficacy

SRI is studying twins to gain more clinical insight into physiologic response to powerful opioid painkillers. Study results should help to optimize pain relief and minimize adverse effects.

Vaccinations and Next-Generation Pandemic Respiratory Viruses

To help prepare for next-generation pandemics, SRI is partnering with Stanford University to examine vaccination responses.

Vitamin A Biosynthesis in Probiotic Bacteria

Vitamin A deficiency causes susceptibility — especially in children — to diarrhea-causing infections, which lead to millions of deaths each year. SRI is developing a probiotic that produces the vitamin.