Article August 1, 2014
5′-AMP-Activated Protein Kinase (AMPK) Supports the Growth of Aggressive Experimental Human Breast Cancer Tumors
Rapid tumor growth can establish metabolically stressed microenvironments that activate 5′-AMP-activated protein kinase (AMPK), a ubiquitous regulator of ATP homeostasis. Previously, we investigated the importance of AMPK for the growth...
Conference Paper April 1, 2013
SR16388 Impairs Protein Homeostasis and Induces Autophagy in Diverse Human Cancer Cell Lines
...orphan nuclear receptor ERRα that has been implicated in the development of various human malignancies. ERRα is thought to regulate tumor cell energy metabolism associated with energy stress within solid...
Blog archive April 1, 2013
The Cell’s Fuel Sensor and Cancer
...maybe hyperactivation of AMPK with a drug could have an antitumor effect… stay tuned. Keith Laderoute is director of SRI’s Cancer Biology Program in the Center for Cancer and Metabolism....
Journal Article March 1, 2012
Ionizing Radiation Regulates the Expression of AMP-Activated Protein Kinase (AMPK) in Epithelial Cancer Cells: Modulation of Cellular Signals Regulating Cell Cycle and Survival
Journal Article January 1, 2012
Transcriptional Regulation of Gene Expression During Osmotic Stress Responses by the Mammalian Target of Rapamycin
Journal Article September 1, 2011
The AMPK Stress Response Pathway Mediates Anoikis Resistance Through Inhibition of mTOR and Suppression of Protein Synthesis
Article March 1, 2011
SR16388: a Steroidal Antiangiogenic Agent with Potent Inhibitory Effecton Tumor Growth in Vivo
...estrogen receptor-α (ER-α) and -β (ER-β) at the nanomolar range. This compound inhibited the proliferation of human microvascular endothelial cells (HMVEC) and various types of human cancer cells in vitro....