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Article August 1, 2014

5′-AMP-Activated Protein Kinase (AMPK) Supports the Growth of Aggressive Experimental Human Breast Cancer Tumors

Rapid tumor growth can establish metabolically stressed microenvironments that activate 5′-AMP-activated protein kinase (AMPK), a ubiquitous regulator of ATP homeostasis. Previously, we investigated the importance of AMPK for the growth...

Conference Paper April 1, 2013

SR16388 Impairs Protein Homeostasis and Induces Autophagy in Diverse Human Cancer Cell Lines

...orphan nuclear receptor ERRα that has been implicated in the development of various human malignancies. ERRα is thought to regulate tumor cell energy metabolism associated with energy stress within solid...

Blog archive April 1, 2013

The Cell’s Fuel Sensor and Cancer

...maybe hyperactivation of AMPK with a drug could have an antitumor effect… stay tuned. Keith Laderoute is director of SRI’s Cancer Biology Program in the Center for Cancer and Metabolism....

Journal Article March 1, 2012

Ionizing Radiation Regulates the Expression of AMP-Activated Protein Kinase (AMPK) in Epithelial Cancer Cells: Modulation of Cellular Signals Regulating Cell Cycle and Survival

Journal Article January 1, 2012

Transcriptional Regulation of Gene Expression During Osmotic Stress Responses by the Mammalian Target of Rapamycin

Journal Article September 1, 2011

The AMPK Stress Response Pathway Mediates Anoikis Resistance Through Inhibition of mTOR and Suppression of Protein Synthesis

Article March 1, 2011

SR16388: a Steroidal Antiangiogenic Agent with Potent Inhibitory Effecton Tumor Growth in Vivo

...estrogen receptor-α (ER-α) and -β (ER-β) at the nanomolar range. This compound inhibited the proliferation of human microvascular endothelial cells (HMVEC) and various types of human cancer cells in vitro....

Journal Article November 1, 2010

The Rational Design of a Novel Potent Analogue of the 5′-AMP-Activated Protein Kinase Inhibitor Compound C with Improved Selectivity and Cellular Activity

Article September 1, 2010

A Novel Steroidal Inhibitor of Estrogen-Related Receptor alpha (ERR alpha)

Journal Article July 1, 2010

5′-AMP-Activated Protein Kinase Activity is Elevated Early During Primary Brain Tumor Development in the Rat

Article January 1, 2010

The Metal-Responsive Transcription Factor-1 Protein Is Elevated in Human Tumors

Article January 1, 2010

SU11248 (Sunitinib) Directly Inhibits the Activity of Mammalian 5′-AMP-Activated Protein Kinase (AMPK)

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