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In the news November 25, 2019

Tiny alterations in training data can introduce “backdoors” into machine learning models

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Keith R. Laderoute

Keith R. Laderoute, is an expert in the biology of the tumor microenvironment. His current research is focused on the regulation of tumor cell energy metabolism, particularly in response to...

Article 2014

5′-AMP-Activated Protein Kinase (AMPK) Supports the Growth of Aggressive Experimental Human Breast Cancer Tumors

Rapid tumor growth can establish metabolically stressed microenvironments that activate 5′-AMP-activated protein kinase (AMPK), a ubiquitous regulator of ATP homeostasis. Previously, we investigated the importance of AMPK for the growth...

Article 2014

Optimal Metabolic Route Search Based on Atom Mappings

...using the menu command [Graphic] RouteSearch and by downloading Pathway Tools. Pathway Tools software is freely available to academic users, and for a fee to commercial users. Download from:

Article 2014

Efficiently Gap-Filling Reaction Networks

...FastGapFilling in MetaFlux as part of Pathway Tools (version 17.5), which is freely available to academic users, and for a fee to commercial users. Download from: Conclusions The computational...

Conference Paper 2013

SR16388 Impairs Protein Homeostasis and Induces Autophagy in Diverse Human Cancer Cell Lines

SR16388 is a novel amino steroid that targets estrogen-binding proteins including genomic estrogen receptors (ERs). Preclinical studies have demonstrated that SR16388 is a well-tolerated, orally active compound with compelling properties...

Journal Article 2012

Ionizing Radiation Regulates the Expression of AMP-Activated Protein Kinase (AMPK) in Epithelial Cancer Cells: Modulation of Cellular Signals Regulating Cell Cycle and Survival

Journal Article 2012

Transcriptional Regulation of Gene Expression During Osmotic Stress Responses by the Mammalian Target of Rapamycin

Journal Article 2011

The AMPK Stress Response Pathway Mediates Anoikis Resistance Through Inhibition of mTOR and Suppression of Protein Synthesis

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