Article April 1, 2015
AT-1001: A High-Affinity alpha3beta4 nAChR Ligand with Novel Nicotine-Suppressive Pharmacology
BACKGROUND AND PURPOSE: The α3β4 subtype of nicotinic acetylcholine receptors (nAChRs) has been implicated in mediating nicotine reinforcement processes. AT-1001 has been recently described as a high-affinity and selective α3β4...
Article February 1, 2015
Varenicline Enhances Dopamine Release Facilitation More Than Nicotine after Long-Term Nicotine Treatment and Withdrawal
An important factor contributing to the high relapse rates among smokers is nicotine withdrawal symptoms. Multiple studies suggest that decreased dopamine release in nucleus accumbens plays a key role in...
Article April 1, 2014
Designing Bifunctional NOP Receptor-Mu-Opioid Receptor Ligands from NOP-Receptor Selective Scaffolds. Part II
The nociceptin opioid receptor (NOP) and its endogenous peptide ligand nociceptin/orphanin FQ have been shown to modulate the pharmacological effects of the classical opioid receptor system. Suppression of opioid-induced reward...
Conference Paper November 1, 2013
AT-202, a Nociceptin Receptor Agonist, Blocks Drug- and Stress-Induced Reinstatement of Extinguished Cocaine Conditioned Place Preference
Central administration of nociceptin/orphanin FQ (N/OFQ), the endogenous agonist peptide ligand for the nociceptin (NOP) receptor, has been shown to block conditioned place preference (CPP) of a variety of abused...
Article January 1, 2013
Retrodialysis of N/Ofq into the Nucleus Accumbens Shell Blocks Cocaine-Induced Increases in Extracellular Dopamine and Locomotor Activity
Journal Article July 1, 2012
Rodent Motor and Neuropsychological Behaviour Measured in Home Cages Using the Integrated Modular Platform SmartCage ™
Journal Article February 1, 2012
Peptides Derived from the Prohormone proNPQ/Spexin are Potent Central Modulators of Cardiovascular and Renal Function and Nociception
Journal Article January 1, 2012
AT-1001: A High Affinity and Selective alpha 3 beta 4 Nicotinic Acetylcholine Receptor Antagonist Blocks Nicotine Self-Administration in Rats
Journal Article November 1, 2011
Differential Effects of Nocicetin/Orphanin FQ (NOP) Receptor Agonists in Acute Versus Chronic Pain: Studies with Bifunctional NOP/μ Receptor Agonists in the Sciatic Nerve Ligation Chronic Pain Model in Mice
Journal Article August 1, 2011
Structural Determinants of Opioid and NOP Receptor Activity in Derivatives of Buprenorphine
Article March 1, 2011
The First Universal Opioid Ligand, (2S)-2-[(5R,6R,7R,14S)-N- Cyclopropylmethyl-4,5-Epoxy-6,14-Ethano-3-Hydroxy-6-Methoxymorphinan-7-Yl]-3, 3-Dimethylpentan-2-Ol (Bu08028): Characterization of the in Vitro Profile and in Vivo Behavioral Effects in Mouse Mo
Article January 1, 2011
Universal Opioid Receptor Ligands – Buprenorphine and Related Orvinols