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Research Scientist, Rogers Laboratory, Center for Neuroscience
Jenny Johansson, Ph.D., focuses on translational research and innate immunity in Alzheimer’s disease. She is interested in how amyloid-beta triggers inflammation but also how the immune system is clearing amyloid from brain and in blood. She studies Alzheimer patients and has a particular interest in disease progression and in developing new disease-relevant models.
Prior to joining SRI, Johansson completed a post-doctoral fellowship in the Neurology and Neurological Sciences Department in the laboratory of Prof. Kati Andreasson at Stanford University. Her main interest was in understanding innate immunity and the roles of peripheral macrophages and brain microglia in models of neuroinflammation and Alzheimer’s disease. She focused on the prostaglandin EP2 receptor, a major transducer of cyclooxygenase (COX) signaling in cell culture, acute in vivo models and a chronic Alzheimer model. In determining inflammation and clearance of amyloid-beta mediated by macrophage and microglial EP2 she characterized a new conditional knock-out model of EP2 in cells of monocytic origin. Her studies involved gene expression, ELISA, brain imaging and behavior.
Johansson received a M.S. in molecular biology from Stockholm University, Sweden. Her Ph.D. is in medical cell biology from the Karolinska Institute in Sweden. Her graduate work was on synapse formation and neurotransmitter and insulin release. She was interested in the role of phosphorylation by cyclin-dependent kinase 5 and SNAP-25 protein isoforms in regulation of exocytosis.