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Home » Archives for Adolf Pfefferbaum » Page 4
Adolf Pfefferbaum

Adolf Pfefferbaum

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Publications

Biomedical sciences publications January 1, 2014

Human Imaging Studies of Brain Circuitry Disrupted by Alcoholism

Adolf Pfefferbaum

Recent scientific advances have provided substantial information on the brain circuits and pathways relevant to various aspects of dependence. 

Biomedical sciences publications December 1, 2013

In Vivo Investigation of Cardiac Metabolism in the Rat Using MRS of Hyperpolarized [1-C-13] and [2-C-13]Pyruvate

Adolf Pfefferbaum, Jaehyeon Park

This work investigates changes in the metabolic fate of acetyl-CoA in response to metabolic interventions of DCA-induced increased PDC flux in the fed and fasted state, and increased cardiac workload with dobutamine in vivo in rat heart at two different pyruvate doses.

Biomedical sciences publications November 1, 2013

Diffustion Tensor Imaging Detects Callosal Fiber Integrity Change over a 1-Year Follow-up in Chronic Alcoholics Who Maintained Sobriety

Eva M Müller-Oehring, Adolf Pfefferbaum, Tilman Schulte

Here, we investigated change in CC microstructural fiber integrity over one year in 12 (7w, 5m) alcoholics (ALC) and 13 (7w, 6m) age-matched controls (CTL). ALC and CTL did not differ in years of education (mean=15 years for both groups) or verbal IQ (CTL=107, ALC=104).

Biomedical sciences publications October 1, 2013

A Selective Insular Perfusion Deficit Contributes to Compromised Salience Network Connectivity in Recovering Alcoholic Men

Eva M Müller-Oehring, Adolf Pfefferbaum

We propose that attenuated insular CBF is a mechanism underlying compromised connectivity among salience network nodes. This local perfusion deficit in alcoholics has the potential to impair ability to switch from cognitive states of interoceptive cravings to cognitive control for curbing internal urges.

Biomedical sciences publications August 1, 2013

Fiber Tract-Driven Topographical Mapping (FTTM) Reveals Microstructural Relevance for Interhemispheric Visuomotor Function in the Aging Brain

Tilman Schulte, Adolf Pfefferbaum

We present a novel approach – DTI-based fiber tract-driven topographical mapping – to map and measure the influence of age on the integrity of interhemispheric fibers and challenge their selective functions with measures of interhemispheric integration of lateralized information.

Biomedical sciences publications June 1, 2013

In Vivo Measurement of Aldehyde Dehydrogenase-2 Activity in Rat Liver Ethanol Model Using Dynamic MRSI of Hyperpolarized [1-(13) C] Pyruvate

Adolf Pfefferbaum

In this work, we show that dynamic MRSI of hyperpolarized pyruvate and its conversion to [1-13C]lactate can provide an indirect in vivo  measurement of ALDH2 activity via the concentration of NADH.

Biomedical sciences publications June 1, 2013

Intrinsic Functional Connectivity in Alcoholism: Test-Retest Stability and Normalization with Sobriety

Eva M Müller-Oehring, Adolf Pfefferbaum, Tilman Schulte

Biomedical sciences publications June 1, 2013

Decision-Making and Brain Structural Substrates in Alcoholism, Hiv Infection, and Their Comorbidity

Adolf Pfefferbaum

Biomedical sciences publications June 1, 2013

Differential Improvement in Neurocognition with Greater Antiretroviral Cns Penetration Effectiveness in Alcoholism-HIV Infection Comorbidity

Adolf Pfefferbaum

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