We report the complete genome sequence of a highly virulent isolate of F. tularensis. The sequence uncovers previously uncharacterized genes encoding type IV pili, a surface polysaccharide and iron-acquisition systems.
Biomedical sciences publications
The E. coli EcoCyc Database: No Longer Just a Metabolic Pathway Database
No longer restricted to metabolic pathways, this curated database includes data on genomics, molecular biology, and more.
A Bayesian method for identifying missing enzymes in predicted metabolic pathway databases
We have developed a method that efficiently combines homology and pathway-based evidence to identify candidates for filling pathway holes in Pathway/Genome databases.
Call for an enzyme genomics initiative
I propose an Enzyme Genomics Initiative, the goal of which is to obtain at least one protein sequence for each enzyme that has previously been characterized biochemically.
Computational Prediction of Human Metabolic Pathways from the Complete Human Genome
We present a computational pathway analysis of the human genome that assigns enzymes encoded therein to predicted metabolic pathways.
Capturing Analytic Thought
We are developing a new methodology that retains the ease of use, the familiarity, and (some of) the free-form nature of informal methods, while benefiting from the rigor, structure, and potential for automation characteristic of formal methods.
A broad host range replicon with different requirements for replication initiation in three bacterial species
To examine initiation events in bacteria unrelated to Escherichia coli, the genes encoding the replicative helicase, DnaB, of Pseudomonas putida and Pseudomonas aeruginosa were isolated and used to construct protein expression vectors.
Integrating Planning and Scheduling through Intensity Adaptation
We describe an incremental and adaptive approach to integrating hierarchical task network planning and constraint-based scheduling.
Structured Argumentation for Analysis
We are developing a new methodology that retains the ease-of-use, familiarity, and (some of) the free-form nature of informal methods, while benefiting from the rigor, structure, and potential for automation characteristic of formal methods.