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Addiction Research

Addiction traps individuals, disrupts families, and affects entire communities. SRI addiction research investigates the causes of addiction, preventive measures, and treatments to stop the downward spiral of addiction.

Nicotine Addiction Research

SRI's Center for Health Sciences has long been recognized for its leading nicotine addiction research. For NIH and other clients, SRI examines the predictors of relapse to nicotine addiction and the influence of genetics on smoking. Nicotine research aims to identify subpopulations at high risk for relapse after nicotine replacement therapy and genetic mutations that may be common among users of alcohol, coffee, and nicotine.

Additional sponsors include the National Heart, Lung, and Blood Institute, the National Institute on Alcohol Abuse and Alcoholism, and the University of California Tobacco-Related Disease Research Fund.

Drug Abuse Research

For clients such as the National Institutes of Health, SRI researchers conduct neuropharmacology studies to discover nonaddictive analgesics. We also perform substance abuse research to investigate the relationship between analgesia and addiction, focusing on opiate receptors and the recently discovered opiate-like receptor ORL1.

To understand the molecular basis of addiction, SRI conducts drug addiction research to study the receptor pharmacology of addictive compounds, including opiates and cocaine analogs. We also conduct drug abuse research for the National Institute on Drug Abuse to generate receptor binding data for the research community at large.

Projects

nicotine molecule with cigarettes

DMET Genes, Nicotine Metabolism, and Prospective Abstinence

Researchers are seeking to identify novel genes contributing to nicotine metabolism and to smoking cessation.

diagram of nicotinic receptors

Role of Nicotinic Receptors in Parkinson’s Disease

SRI is investigating whether the nicotine in tobacco smoke may be useful in meeting the urgent need to manage Parkinson’s disease.

cigarette being snapped in half

Treatment of Nicotine Dependence in a Healthcare Setting

SRI is analyzing the genetics of smoking and related characteristics, using data from a large-scale National Cancer Institute study on smoking cessation.

man putting out a cigarette in an ashtray

Salivary Biomarkers, Life Stress & Nicotine Dependence

This project could advance drug abuse prevention and intervention research by identifying Genetic x Environment (GxE) interactions, which may help explain the development of nicotine dependence. Results may guide development of tailored interventions.