Bioinformatics and Computational Biology | SRI International

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Bioinformatics and Computational Biology

Applying computational methods to the study of living systems at all scales—from molecules to ecosystems—advances scientific understanding. For example, researchers can now use computer programs to generate a quantitative metabolic model from a sequenced genome.

SRI's interdisciplinary scientists develop tools, software, databases, and ontologies to manage and analyze the burgeoning quantities of biological data and knowledge now available. These tools can be applied to applications ranging from accelerating drug discovery to developing new biofuels. Our symbolic systems biology researchers also perform formal reasoning about computers and biological systems.

Projects and offerings include:

  • Pathway Logic: a powerful approach to modeling biological entities and processes, such as metabolic networks and signal transduction

  • BioCyc: a collection of more than 3,000 databases containing information about genomes and biochemical pathways

  • Pathway Tools: bioinformatics software for pathway analysis of genomes and for creating quantitative metabolic models

  • HumanCyc: a bioinformatics database linking human metabolic pathways to the human genome

  • MetaCyc: a database of nonredundant, experimentally elucidated metabolic pathways that contains 2,100 pathways from thousands of different organisms, and is curated from the scientific experimental literature

  • Biological Simulation Program for Intra- and Inter-Cellular Evaluation (Bio-SPICE): an open-source computing environment that biologists can modify and control

  • Hybrid qualitative modeling/hybrid quantitative modeling: SRI's approach to analyzing complex biological systems based on simultaneously modeling a system’s continuous and discrete behaviors using the HybridSAL language

In our work, we often engage researchers, biologists, and computer scientists at other R&D organizations.


two researchers looking at computer screens

MetaCyc Metabolic Pathway Database

MetaCyc is a curated database of experimentally elucidated metabolic pathways from all domains of life. MetaCyc contains 2260 pathways from 2600 different organisms.

silhouette of a man looking at BioCyc software

BioCyc Database Collection

A comprehensive website for sharing fundamental information about biochemical pathways and genomes with researchers around the world.