Sleep Research | SRI International

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Sleep Research

Healthy sleep is vital to an individual's well-being, productivity, and long-term health. SRI Biosciences conducts clinical and basic research studies about sleep and sleep disorders to better understand the causes and consequences of sleep disruption at the molecular, neurological, and behavioral levels. This research can lead to treatments for insomnia, jet lag, age-related sleep disturbances, fatigue, and narcolepsy.

Human Sleep Studies

We conduct basic and translational research on sleep, including how the brain’s structure and function relate to sleep across development in adolescents as well as in adults.

For the National Institutes of Health (NIH) and other clients, we use cognitive tests, electroencephalography (EEG) measures, and innovative magnetic resonance imaging (MRI) techniques. Other methodologies include measures of cardiovascular system function, electrophysiology, and behavioral testing.

Better Sleep Treatments

We also conduct research on sleep and sleep disorders, using methodologies such as molecular biology, electrophysiology, microdialysis, and behavioral testing. Our work includes National Institutes of Health-sponsored studies on the neurobiology of sleep and wakefulness and treatments for narcolepsy.

We validate novel therapeutic targets and conducts in vitro and in vivo efficacy and safety assessments. Our translational research focus has provided critical proof-of-concept studies to support FDA Investigational New Drug (IND) files for several central nervous system indications. For medical device developers, we also conduct FDA 510(k) trials.

SRI researchers discovered hypocretin/orexin (H/Hcrt), a neuropeptide system that stimulates arousal and is involved in sleep regulation. Using differential gene expression approaches, SRI is studying the relationship between the H/O system and sleep disorders. SRI announced a promising new treatment for narcolepsy in 2014.

Projects

Alcohol, Sleep and Health

Volunteers wanted for study on alcohol’s effects

brain scan

Treatments for Narcolepsy

SRI sleep researchers are working to discover and develop new treatments for narcoleptic patients.

glowing blue neuron

Neurobiology of Sleep and Wakefulness

SRI takes an integrated approach to understand the systems that control sleep and wakefulness.

man lying awake with his head on a pillow

Brain Changes Associated with Sleep Deprivation

Lack of sleep can lead to a range of cognitive, attention, and emotional deficits. SRI and its partner have made a thorough study of its effects on the brain.