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Projects

Volunteers wanted for study on alcohol’s effects
scientist working at a computer
SRI has developed a promising new treatment for this cancer of the immune system that affects plasma cells in bone marrow.
bioscience workers in a lab
SRI is conducting preclinical development of treatments for diseases such as tuberculosis, West Nile virus, hepatitis, and biodefense pathogens and toxins.
silhouette of a man looking at BioCyc software
A comprehensive website for sharing fundamental information about biochemical pathways and genomes with researchers around the world.
row of vials containing glowing material
In a nuclear or radiological incident, first responders must quickly measure the radiation exposure of a large number of individuals, since treatment options are radiation dose-dependent and time-sensitive. SRI is developing a biodosimeter to meet this critical challenge.
scientist with a computer model of a molecular structure
SRI is identifying candidates for advanced therapies in multiple disease areas by developing compounds from synthetically optimized, natural dietary products.
man lying awake with his head on a pillow
Lack of sleep can lead to a range of cognitive, attention, and emotional deficits. SRI and its partner have made a thorough study of its effects on the brain.
group of teens sitting together on the grass
SRI’s Sleep Research Laboratory in Menlo Park, California is currently recruiting for this study.
SRI’s Brown Laboratory is utilizing cell-targeting peptides to deliver active therapeutic cargo to specific cells in vivo.
monoclonal antibodies
Novel molecular targets of several cytokines are being evaluated by SRI scientists, with the goal of designing a small-molecule drug to block responses involved in many of these inflammatory diseases.
nicotine molecule with cigarettes
Researchers are seeking to identify novel genes contributing to nicotine metabolism and to smoking cessation.
scientist drawing a chemical structure
SRI is developing a novel point-of-care tool for the early detection of devastating diseases.
EcoCyc logo
EcoCyc is SRI's bioinformatics database that describes the genome and the biochemical machinery of Escherichia coli.
young girl at an activity station, looking up at the camera
SRI examined the effectiveness of academic, social/behavioral, and vocational interventions for students with autism.
a high-throughput fluorescence polarization assay
SRI is seeking new treatments for tuberculosis, a global health crisis.
The Integrin αvβ6 Increases During the Pathogenesis of Squamous Cell Carcinoma of the Lung
SRI’s Brown Laboratory is using selected peptides as “fishing hooks” to identify novel cell surface features.
scientist working at a computer
SRI is investigating novel methods and treatments to improve cognitive deficits caused by diseases such as Alzheimer’s and depression.
chemical diagram
SRI is developing a new therapeutic agent for influenza virus infections.
Innovative Science Overcomes Formulation Challenges
chart
SRI is elucidating the mechanism of action of the drug of choice for the treatment of all known forms of human schistosomiasis.
SRI researcher working with lab equipment
SRI is enabling and improving metabolomics research with high-quality reference standards.
two researchers looking at computer screens
MetaCyc is a curated database of experimentally elucidated metabolic pathways from all domains of life. MetaCyc contains 2500 pathways from 2800 organisms.
an SRI researcher examines a medical device prototype
To address a critical healthcare need, SRI is partnering to develop medical devices for treating children.
scientist checking a batch of vaccines
SRI has patented a novel approach to vaccine delivery that is safe for pediatric use, eliminating the need for painful injections.
glowing blue neuron
SRI takes an integrated approach to understand the systems that control sleep and wakefulness.
scientist working with a chelating agent
A new oral version of a known chelating agent can defend against mass radiation exposure in a terrorist attack.
Partnering to Advance Therapy for Radiation Exposure
Partnering to Rapidly Advance ZMapp® for Ebola Treatment
gloved hand inserting a cartridge into the sentinel device
From raw sample to molecular results in minutes: The Sentinel Nucleic Acid Analysis System offers portable, real-time diagnosis of health conditions.
SRI, Stanford University, and PARC co-developed an intelligent system for answering English questions about HIV treatment.
chest x-ray using SRI's tomographic imaging source
SRI is developing technologies that could significantly improve tomographic medical imaging for cancer treatment and research.
nicotinic receptors affect brain activity
To support more effective cessation treatments, SRI researchers are exploring how nicotinic receptors affect brain activity in response to smoking.
diagram of nicotinic receptors
SRI is investigating whether the nicotine in tobacco smoke may be useful in meeting the urgent need to manage Parkinson’s disease.
man putting out a cigarette in an ashtray
This project could advance drug abuse prevention and intervention research by identifying Genetic x Environment (GxE) interactions, which may help explain the development of nicotine dependence. Results may guide development of tailored interventions.
middle-aged woman relaxing on bed
Sleep complaints are common during the transition to menopause, yet we have little understanding of what drives this increase in sleep disturbance and how best to treat it. SRI researchers are investigating sleep quality in women who have begun to go through menopause.
gloved hand catching pill capsules coming out of a dispenser
Through a broad range of services for the National Institutes of Health, SRI is accelerating preclinical development of potential therapies for diseases that affect millions of people.
graphic showing the hypothetical pharmacophore features for herboxidiene
SRI researchers are searching for new molecular targets that allow for discovery of more selective anticancer agents.
boy sitting at computer at the library
SRI examined data on 900 young adults with autism to characterize their school and career choices after high school.
microscope
SRI is developing a method to enable rapid, large-scale response to a bioterrorism threat or an infectious disease epidemic.
A peptide that targets dendritic cells delivers quantum dots intracellularly.
SRI's Brown Laboratory is taking multiple approaches to develop effective anti-cancer immunotherapies.
scientist looking through a microscope
For the National Institute of Mental Health (NIMH), SRI performs preclinical safety and pharmacokinetics studies for brain imaging agents and drugs to treat mental illnesses.
the prototypical Trauma Pod operating suite
With SRI as lead integrator, DARPA collaborators demonstrated how a remotely operated trauma pod could deliver emergency first-response treatment in the battlefield to stabilize patients for transport.
cigarette being snapped in half
SRI is analyzing the genetics of smoking and related characteristics, using data from a large-scale National Cancer Institute study on smoking cessation.
brain scan
SRI sleep researchers are working to discover and develop new treatments for narcoleptic patients.
twin boys
SRI established the Twin Research Registry as part of its scientific research and efforts to discover more about human behavior. Fraternal and identical twins and multiples of all ages are invited to join the Registry for consideration for research studies.
Using synthetic lethality to ID biomarkers for targeted anti-cancer drugs.
Twins on bicycles
SRI studied twins to gain more clinical insight into physiologic response to powerful opioid painkillers. Study results should help to optimize pain relief and minimize adverse effects.
An SRI vaccine researcher in protective clothing and a mask
To help prepare for next-generation pandemics, SRI is partnering with Stanford University to examine vaccination responses.
hand holding a petri dish of bacterial culture up to the light
Vitamin A deficiency causes susceptibility — especially in children — to diarrhea-causing infections, which lead to millions of deaths each year. SRI is developing a probiotic that produces the vitamin.