DMET Genes, Nicotine Metabolism, and Prospective Abstinence | SRI International

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DMET Genes, Nicotine Metabolism, and Prospective Abstinence

Researchers are seeking to identify novel genes contributing to nicotine metabolism and to smoking cessation.

The objectives of the research are to identify novel genes contributing to nicotine metabolism and to smoking cessation. Nicotine metabolism is associated with the number of cigarettes smoked per day (CPD), how cigarettes are smoked (smoking topography), with responsiveness to smoking cessation treatment, and with carcinogen activation and level.

Enhanced knowledge of the genes that influence nicotine metabolism and smoking cessation clinical trial outcomes will identify novel targets for the development of smoking cessation therapies, and may help personalize smoking cessation treatment and genetic risk assessment for smoking-attributable disease.