Vaccinating Against Next-Generation Pandemic Respiratory Viruses | SRI International

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Vaccinations and Next-Generation Pandemic Respiratory Viruses

To help prepare for next-generation pandemics, SRI is partnering with Stanford University to examine vaccination responses.

This study about protecting against future respiratory virus pandemics makes use of SRI’s expanding Twin Research Registry, providing valuable information about vaccination responses. With Stanford University, SRI is working to

  • Extend knowledge about immune responses to influenza vaccine, analyzing responses among different age groups and different modes of vaccine delivery
  • Explore the influence of genetics on human immune response to influenza vaccination, using evidence from pairs of twins, both identical (monozygotic) and fraternal (dizygotic)

SRI is using Stanford University’s analyses of immune responses to the two licensed influenza vaccines to establish a unique data set. In measuring components of immune system response, the researchers are gaining insight into specific biomarkers that indicate either healthy and effective response, or problematic reactions. In particular, the collaborators are looking at responses of the immune system’s B and T cells – their range of behavior, signaling molecules, and pathways.

Members of SRI's Twin Research Registry form the core of the subject base because they enable the analysis of the genetics of the immune response across different age levels.