Treating Cognitive Deficits across Neuropsychiatric Disorders | SRI International

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Improving Cognitive Deficits

SRI is investigating novel methods to treat cognitive deficits caused by neuropsychiatric disorders such as Alzheimer’s and depression.

Cognitive deficits, such as a decline in memory, attention, and decision-making ability, are an integral component of many diseases such as Alzheimer's, Parkinson's, depression, and schizophrenia. They may also occur after long periods without sleep, impacting an individual's judgment, intellectual function, and performance. Cognition is of great scientific interest because it is a highly complex function impacted by many factors, including aging, disease, and stress.

In collaboration with F. Hoffmann-La Roche, scientists at SRI’s Center for Neuroscience are developing new methods to assess cognitive deficits. Researchers are also identifying new medicines to improve cognitive impairments associated with neurological and psychiatric conditions. SRI researchers assess cognitive function using neuropsychological tests (e.g., the Cambridge Neuropsychological Test Automated Battery) and measures (e.g., electroencephalography and eye-tracking), among other methods.

The ultimate goal is to translate basic science discoveries into innovative central nervous system therapies to help people with cognitive impairments.