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Home » Archives for Paul O’Maille
Paul O’Maille

Paul O’Maille

Program Director, Biocomplexity Sciences, SRI International
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Publications

Biomedical sciences publications March 28, 2023

Emergence of terpene chemical communication in insects: Evolutionary recruitment of isoprenoid metabolism

Paul O’Maille

We present the first structural and mechanistic model for the evolutionary emergence of TPS function in insects. Through identifying key mechanistic differences between IDS and TPS enzymes, we hypothesize that the loss of isopentenyl diphosphate (IPP) binding motifs strongly correlates with the gain of the TPS function.

Biomedical sciences publications January 15, 2023

Ancient origin and conserved gene function in terpene pheromone and defense evolution of stink bugs and hemipteran insects 

Paul O’Maille

The origin of enzymes involved in terpene biosynthesis and their evolution in insect genomes is still poorly understood. We addressed this question by investigating the evolution of isoprenyl diphosphate synthase (IDS)-like genes with terpene synthase function in the family of stink bugs.

Biomedical sciences publications July 7, 2020

Sparse epistatic patterns in the evolution of terpene synthases

Paul O’Maille

We explore sequence determinants of enzyme activity and specificity in a major enzyme family of terpene synthases.

Biomedical sciences publications August 16, 2019

Resources to discover and use short linear motifs in viral proteins

Paul O’Maille, Andrew Silberfarb

We survey viral uses of SLiMs to mimic host proteins, and information resources available for motif discovery.

Biomedical sciences publications May 2, 2019

Using pathway covering to explore connections among metabolites

Paul O’Maille, Peter Karp

Pathway Covering is a new algorithm that takes a list of metabolites (compounds) and determines a minimum-cost set of metabolic pathways in an organism that includes (covers) all the metabolites in the list.

Biomedical sciences publications October 13, 2017

The Omics Dashboard for interactive exploration of gene-expression data

Peter Karp, Paul O’Maille, Suzanne Paley

The Omics Dashboard is a software tool for interactive exploration and analysis of gene-expression datasets.

Publication January 1, 2016

Pathway collages: personalized multi-pathway diagrams

Peter Karp, Suzanne Paley, Paul O’Maille, David Weaver

We define software for constructing personalized multi-pathway diagrams called pathway-collages using a combination of manual and automatic layouts.

Biomedical sciences publications February 3, 2015

Emergence of terpene cyclization in Artemisia annua

Paul O’Maille

Here we report the first discovery of an epistatic network of residues that controls the onset of terpene cyclization in Artemisia annua.

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