The discovery of safe and effective radiation countermeasures for long-duration spaceflight is challenging due to the complexity of the space radiation biology and high safety requirements.
Mega-High-Throughput Screening Platform for the Discovery of Biologically Relevant Sequence-Defined Non-Natural Polymers
We developed a novel technology for screening and sequencing libraries of synthetic molecules of up to a billion compounds in size.
Expanding the Metabolite Mimic Approach to Identify Hits for Mycobacterium Tuberculosis
A Systematic Screen of FDA-Approved Drugs for Inhibitors of Biological Threat Agents
The feasibility of repurposing existing drugs to face novel threats is demonstrated and this represents the first effort to apply this approach to high containment bacteria and viruses.
Systematic Discovery of Synergistic Novel Antibiotic Combinations Targeting Multidrug-Resistant Acinetobacter Baumannii
Combining Cheminformatics Methods and Pathway Analysis to Identify Molecules with Whole-Cell Activity Against Mycobacterium Tuberculosis
Our approach leverages the integration of intensive data mining and curation and computational approaches, including cheminformatics combined with bioinformatics, to suggest biological targets and their small molecule modulators.
Discovery and Optimization of Benzotriazine Di-N-Oxides Targeting Replicating and Nonreplicating Mycobacterium Tuberculosis
These data along with measurements of the physiochemical properties and pharmacokinetic profile demonstrate that BTOs have the potential to be developed into a new class of antitubercular drugs.
Bulged DNA Substrates for Identifying Poxvirus Resolvase Inhibitors
We report an assay for resolvase cleavage activity based on fluorescence polarization (FP) for high-throughput screening and mechanistic studies.
Evaluation of Gyrase B as a Drug Target in Mycobacterium Tuberculosis
Aminobenzimidazole inhibitors of GyrB exhibit many of the characteristics required for their consideration as a potential front-line antimycobacterial therapeutic.