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Home » Archives for Peter Madrid
Peter Madrid

Peter Madrid

Publications

Biomedical sciences publications November 21, 2022

Accelerating space radiation countermeasure development through drug repurposing 

Peter Madrid

The discovery of safe and effective radiation countermeasures for long-duration spaceflight is challenging due to the complexity of the space radiation biology and high safety requirements.

Biomedical sciences publications January 11, 2022

Mega-High-Throughput Screening Platform for the Discovery of Biologically Relevant Sequence-Defined Non-Natural Polymers 

Peter Madrid

We developed a novel technology for screening and sequencing libraries of synthetic molecules of up to a billion compounds in size.

Information & computer science publications August 1, 2014

Expanding the Metabolite Mimic Approach to Identify Hits for Mycobacterium Tuberculosis

Carolyn Talcott, Peter Madrid

Biomedical sciences publications April 1, 2013

A Systematic Screen of FDA-Approved Drugs for Inhibitors of Biological Threat Agents

Peter Madrid, Carol Green

The feasibility of repurposing existing drugs to face novel threats is demonstrated and this represents the first effort to apply this approach to high containment bacteria and viruses.

Biomedical sciences publications August 1, 2012

Systematic Discovery of Synergistic Novel Antibiotic Combinations Targeting Multidrug-Resistant Acinetobacter Baumannii

Peter Madrid

Biomedical sciences publications August 1, 2012

Combining Cheminformatics Methods and Pathway Analysis to Identify Molecules with Whole-Cell Activity Against Mycobacterium Tuberculosis

Carolyn Talcott, Peter Madrid

Our approach leverages the integration of intensive data mining and curation and computational approaches, including cheminformatics combined with bioinformatics, to suggest biological targets and their small molecule modulators.

Biomedical sciences publications June 1, 2012

Discovery and Optimization of Benzotriazine Di-N-Oxides Targeting Replicating and Nonreplicating Mycobacterium Tuberculosis

Peter Madrid

These data along with measurements of the physiochemical properties and pharmacokinetic profile demonstrate that BTOs have the potential to be developed into a new class of antitubercular drugs.

Biomedical sciences publications May 1, 2012

Bulged DNA Substrates for Identifying Poxvirus Resolvase Inhibitors

Peter Madrid

We report an assay for resolvase cleavage activity based on fluorescence polarization (FP) for high-throughput screening and mechanistic studies.

Biomedical sciences publications November 1, 2011

Evaluation of Gyrase B as a Drug Target in Mycobacterium Tuberculosis

Peter Madrid

Aminobenzimidazole inhibitors of GyrB exhibit many of the characteristics required for their consideration as a potential front-line antimycobacterial therapeutic.

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