Research Associate, Formulation R&D, Applied Research
Shravan K Mutyam researches pharmaceutical excipients and their functionalities to develop pre-clinical and clinical pharmaceutical formulations. He is involved in formulation development efforts of several drug candidates including NCEs for animal toxicology, PK-PD and bioavailability studies – specifically molecules with poor solubility and permeability by developing enabling formulations.
Mutyam designs and assists in development of preclinical formulations from lab scale to Phase I clinical formulations. He has worked with formulation development of diverse dosage forms including oral solid dosage forms (tablets and capsules), immediate release/modified release dosage forms, lipid-based formulations, maltiparticulate bead capsule formulations, solutions, suspensions, microspheres, powder in bottle, vaccines, emulsions, spray dried dispersions (SDD), self-emulsifying drug delivery systems (SEDDS), parenteral and transdermal formulations.
Mutyam received his M.S. in Chemistry from Lamar University, Beaumont, Texas and holds a certificate in Project Management (Life Sciences and Drug Development) from University of California, Berkeley Ext. He has a bachelor’s degree in pharmaceutical sciences (bachelor of pharmacy) from Osmania University, Hyderabad, India and a diploma in pharmacy from Govt. Polytechnic, Hyderabad, India.
Formulation Approaches to Improving the Delivery of an Antiviral Drug with Activity against Seasonal Flu
The main objective of the present study was to develop formulations of noscapine hydrochloride hydrate with enhanced solubility and bioavailability using co-solvent- and cyclodextrin-based approaches.
Tablet formulation of an active pharmaceutical ingredient with a sticking and filming problem: direct compression and dry granulation evaluations
Direct compression and dry granulation tableting techniques were evaluated using factorial experimental design.
Permeability Enhancing Lipid-Based Co-Solvent and SEDDS Formulations of SQ641, an Antimycobacterial Agent
The objective of this study was to develop an oral preclinical liquid formulation of SQ641 and to determine the permeability across rat intestinal tissue by Ussing chamber.