The EcoCyc and MetaCyc Databases


Karp, P.D., Riley, M., Paulsen, I.T., Paley, S., Pellegrini-Toole, A. The EcoCyc and MetaCyc Databases. Nucleic Acids Research, vol. 28, no. 1, pp. 56-59, 2000.


EcoCyc is an organism-specific Pathway/Genome Database that describes the metabolic and signal-transduction pathways of Escherichia coli, its enzymes, and—a new addition—its transport proteins. MetaCyc is a new metabolic-pathway database that describes pathways and enzymes of many different organisms, with a microbial focus. Both databases are queried using the Pathway Tools graphical user interface, which provides a wide variety of query operations and visualization tools. EcoCyc and MetaCyc are available at

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