A. Diamino-1,2,4-Triazole Derivatives are Selective Inhibitors of TYK2 and JAK1 Over JAK2 and JAK3

Citation

Copy to clipboard

Malerich, J. P., Lam, J. S., Hart, B., Fine, R. M., Klebansky, B., Tanga, M. J., & D’Andrea, A. (2010). Diamino-1, 2, 4-triazole derivatives are selective inhibitors of TYK2 and JAK1 over JAK2 and JAK3. Bioorganic & medicinal chemistry letters, 20(24), 7454-7457.

Abstract

Tyrosine kinase 2 (TYK2) is required for signaling of interleukin-23 (IL-23), which plays a key role in rheumatoid arthritis. Presented is the design and synthesis of 1,2,4-triazoles, and the evaluation of their inhibitory activity against the Janus associated kinases TYK2 and JAKs 1–3.

↓ View online