A Regression Model for Risk Difference Estimation in Population-Based Case-Control Studies Clarifies Gender Differences in Lung Cancer Risk of Smokers and Never Smokers


Kovalchik, S. A., De Matteis, S., Landi, M. T., Caporaso, N. E., Varadhan, R., Consonni, D., . . . Wacholder, S. (2013). A regression model for risk difference estimation in population-based case-control studies clarifies gender differences in lung cancer risk of smokers and never smokers. BMC Medical Research Methodology, 13, 143.


Additive risk models are necessary for understanding the joint effects of exposures on individual and population disease risk. Yet technical challenges have limited the consideration of additive risk models in case–control studies.

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