Citation
Malerich, J. P., Li, J., Joder, D., Vieria, Ć. L. M., Keesen, T. S. L., Vaidyanathan, R., . . . Tanga, M. J. (2013). Antileishmanial activity of natural product-like naphthoquinones. Drug Development Research, 74(4), 237-241. doi: 10.1002/ddr.21067
Abstract
The antileishmanial activity of compounds inspired by naphthoquinone secondary metabolites fromĀ BignoniaceaeĀ is presented. Three structural series of compounds from a common biosynthetic pathway were evaluated againstĀ Leishmania major. Compound (15), an analog of the natural product pinnatal, was more active than amphotericin B againstĀ L.āmajor. When tested againstĀ L. (Viannia) braziliensisĀ andĀ L.āinfantum, compoundĀ 15Ā showed similar activity to amphotericin B.
