Antileishmanial Activity of Natural Product-Like Naphthoquinones

Citation

Malerich, J. P., Li, J., Joder, D., Vieria, É. L. M., Keesen, T. S. L., Vaidyanathan, R., . . . Tanga, M. J. (2013). Antileishmanial activity of natural product-like naphthoquinones. Drug Development Research, 74(4), 237-241. doi: 10.1002/ddr.21067

Abstract

The antileishmanial activity of compounds inspired by naphthoquinone secondary metabolites from Bignoniaceae is presented. Three structural series of compounds from a common biosynthetic pathway were evaluated against Leishmania major. Compound (15), an analog of the natural product pinnatal, was more active than amphotericin B against L. major. When tested against L. (Viannia) braziliensis and L. infantum, compound 15 showed similar activity to amphotericin B.

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