Carbon-14 Labeling of K777


Rhee, S.-W., Bradford, W. W., Malerich, J. P., & Tanga, M. J. (2013). Carbon-14 labeling of K777


The antitrypanosomal agent K777•HCl was labeled with carbon-14 to support absorption, distribution, metabolism, and excretion studies of this potential new drug for the treatment of Chagas disease. The radiolabeled compound was prepared in eight steps from [14C(U)]-(l)-phenylalanine with a specific activity of 54.4 mCi/mmol and an overall radiochemical yield of 4.1%.

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