Cerebral Dynamics and Metabolism of Hyperpolarized 1- 13 Cpyruvate Using Time-Resolved Mr Spectroscopic Imaging


Hurd RE, Yen Y-F, Tropp J, Pfefferbaum A, Spielman DM, Mayer D. Cerebral Dynamics and Metabolism of Hyperpolarized [1-13C]pyruvate Using Time-Resolved MR Spectroscopic Imaging. Journal of Cerebral Blood Flow & Metabolism. 2010;30(10):1734-1741. doi:10.1038/jcbfm.2010.93


Dynamic hyperpolarized [1-13C]pyruvate metabolic imaging in the normal anesthetized rat brain is demonstrated on a clinical 3-T magnetic resonance imaging scanner. A 12-second bolus injection of hyperpolarized [1-13C]pyruvate is imaged at a 3-second temporal resolution. The observed dynamics are evaluated with regard to cerebral blood volume (CBV), flow, transport, and metabolic exchange with the cerebral lactate pool. A model for brain [1-13C]lactate, based on blood–brain transport kinetics, CBV, and the observed pyruvate dynamics is described.

Keywords: blood–brain transport; cerebral blood volume; hyperpolarized-13C; lactate; pyruvate; rat brain

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