• Skip to primary navigation
  • Skip to main content
SRI logo
  • About
    • Press room
    • Our history
  • Expertise
    • Advanced imaging systems
    • Artificial intelligence
    • Biomedical R&D services
    • Biomedical sciences
    • Computer vision
    • Cyber & formal methods
    • Education and learning
    • Innovation strategy and policy
    • National security
    • Ocean & space
    • Quantum
    • Robotics, sensors & devices
    • Speech & natural language
    • Video test & measurement
  • Ventures
  • NSIC
  • Careers
  • Contact
  • 日本支社
Search
Close
Biomedical sciences publications February 1, 2014

Glyco-Epitope Diversity: An Evolving Area of Glycomics Research and Biomarker Discovery

Citation

Copy to clipboard


Wang, D. (2014). Glyco-epitope diversity: an evolving area of glycomics research and biomarker discovery. Journal of Proteomics & Bioinformatics, 7(2). doi: 10.4172/jpb.10000e24

Abstract

Although the term “glyco code” has only recently come into use [1-4], recognition of the carbohydrate signatures of microbes was documented nearly a century ago. In 1917, Dochez and Avery [5] found that when Pneumococci were grown in fluid media, there was a substance in the culture fluid that precipitated specifically with antisera to the same Pneumococcus. Heidelberger and Avery [6] showed that the substance recognized by the antibodies was a carbohydrate molecule and not a protein, as previously thought. It was later found that almost every microorganism expresses such glyco codes that are recognized by the host immune systems and are effective in stimulating specific antibody responses [7,8]. Such immunogenic carbohydrate moieties offen serve as key targets for development of vaccines against infectious diseases [9-13]. Tumor glycomics research in recent years has uncovered a large panel of tumor-associated carbohydrate antigens [14,15] and evidence of immune recognition of tumor-derived aberrant carbohydrates [16-20].

↓ View online

Share this
Career call to action image

Work with us

Search jobs

How can we help?

Once you hit send…

We’ll match your inquiry to the person who can best help you.

Expect a response within 48 hours.

Our work

Case studies

Publications

Timeline of innovation

Areas of expertise

Institute

Leadership

Press room

Media inquiries

Compliance

Careers

Job listings

Contact

SRI Ventures

Our locations

Headquarters

333 Ravenswood Ave
Menlo Park, CA 94025 USA

+1 (650) 859-2000

Subscribe to our newsletter


日本支社
SRI International
  • Contact us
  • Privacy Policy
  • Cookies
  • DMCA
  • Copyright © 2023 SRI International
Manage Cookie Consent
To provide the best experiences, we use technologies like cookies to store and/or access device information. Consenting to these technologies will allow us to process data such as browsing behavior or unique IDs on this site. Not consenting or withdrawing consent, may adversely affect certain features and functions.
Functional Always active
The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.
Preferences
The technical storage or access is necessary for the legitimate purpose of storing preferences that are not requested by the subscriber or user.
Statistics
The technical storage or access that is used exclusively for statistical purposes. The technical storage or access that is used exclusively for anonymous statistical purposes. Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you.
Marketing
The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes.
Manage options Manage services Manage {vendor_count} vendors Read more about these purposes
View preferences
{title} {title} {title}