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Abstract
This chapter frames important issues in identifying potential phenotypes of nicotine dependence and sets the stage for examining the role of genetics in nicotine-dependence research. Key areas discussed include
■ Issues in the defi nition and measurement of nicotine dependence
■ A framework for phenotypes for nicotine dependence that potentially links genetics and behavioral traits while showing measurable validity, reliability, and heritability
■ The implications of epidemiological concepts in identifying potentially complex genetic risk factors for nicotine dependence
■ Measuring environmental infl uences and including them in models of estimates of genetic risk and the role epigenetic investigations will play in future investigations
■ A review of selected biometric and genetic studies of nicotine dependence
■ The communication and interpretation of fi ndings from genetic studies of nicotine dependence, including the need for replication, the potential for stigmatization, and value of direct-to-consumer marketing of genetic tests based on these findings.
This volume examines conceptual, theoretical, and methodological considerations in the development of nicotine-dependence phenotypes and endophenotypes. Each of these areas shows the potential for future study to help better understand factors in global tobacco use.