Synthesis of a 35S-Labeled Dinucleoside Phosphorothioate Prodrug, an Orally Bioavailable Anti-HBV Agent


Rhee, S. W., Iyer, R. P., Coughlin, J. E., Padmanabhan, S., Malerich, J. P., & Tanga, M. J. (2012). Synthesis of a 35S-labeled dinucleoside phosphorothioate prodrug, an orally bioavailable anti‐HBV agent. Journal of Labelled Compounds and Radiopharmaceuticals, 55(6), 197-200.


The 35S-labeled, dinucleoside phosphorothioate 1, an orally available agent against hepatitis B virus, was prepared in eight steps with high specific activity and radiochemical purity. Radiolabeled 3H-benzodithiole-3-one-1,1-dioxide was synthesized in four steps from 35S8 and was used as the sulfurizing reagent.

Copyright © 2012 John Wiley & Sons, Ltd.

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