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Biomedical sciences publications January 1, 2009 Journal Article

Tobacco Addiction and Pharmacogenetics of Nicotine Metabolism

SRI International January 1, 2009

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Tobacco Addiction and Pharmacogenetics of Nicotine Metabolism, Gary E. Swan , Christina N. Lessov-Schlaggar, Journal of Neurogenetics, Vol. 23, Iss. 3, 2009

Abstract

This paper presents a brief overview of several components of tobacco addiction, including: 1) the epidemiology of smoking in the United States and elsewhere around the world; 2) implications of the pharmacogenetic study of nicotine metabolism for understanding tobacco addiction and its treatment; 3) the use of the twin design as an example of one strategy to understand the contribution of genetic and environmental factors to the pharmacokinetics of nicotine metabolism; 4) results from recent genomic studies of tobacco addiction in adults; and 5) a discussion of progress (past and future) toward the development of a comprehensive understanding of the pharmacogenetics of tobacco addiction and its treatment.

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