Miniaturized opto-fluidic system for on-the-flow analyte characterization based on spatial modulation technique

Citation

Kiesel, P.; Martini, J.; Recht, M. I.; Bern, M. W.; Johnson, N. M. Miniaturized opto-fluidic system for on-the-flow analyte characterization based on spatial modulation technique. Proceedings of 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2013); 2013 October 27-31; Freiburg, Germany.

Abstract

A compact opto-fluidic detection platform for on-the-flow analyte characterization is described. The performance is demonstrated with recent results for water-borne pathogens. Results are obtained for Giardia, Cryptosporidium, and E. Coli, with reliable identification and enumeration of the pathogens at meaningfully low concentrations. Incubation studies with antibody-based reagents show that for Giardia incubation times as short as 2 min and analyte-to-reagent ratios as low as 1:100 are sufficient for reliable detection. And the antibody-based reagents (in liquid form) are highly stable, with little degradation over a period of months at 37 degrees C.

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