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Biomedical sciences

SRI Biosciences delivers next-generation drugs, diagnostics and devices to solve unmet medical needs. We work with partners to develop transformative approaches and platforms for the toughest therapeutic problems.

CONTACT US

Areas of expertise

Collaborative research

Neuroimaging and electrophysiological research

Sleep device design and validation

Adolescent development

Translational approaches using in vivo MRI

Translational neuroscience

Drug discovery

Technology platforms for new approaches to drug discovery

Small molecule and biologic therapies

AI-driven drug design

Target validation and assay development and screening

Lead identification, optimization and synthesis

Diagnostics and devices

Fiber-optic Array Scanning Technology (FAST) rare cell detection

High-speed hyperspectral imaging

Wearable sleep technology

Diagnostic biomarker discovery

SynFini: automated chemistry design and synthesis

Chemical and biological sensing solutions

Product development services

Pharmacology, efficacy and predictive ADMET

Safety, drug metabolism and pharmacokinetics

Formulation design

Clinical drug product manufacturing

Clinical trials

Our latest

more +

  • Ovid adds BioCyc Pathway/Genome Databases to support genomic researchers
    July 7, 2022

    Ovid adds BioCyc Pathway/Genome Databases to support genomic researchers

    To increase researchers’ access to comprehensive data, Wolters Kluwer expanded Ovid® with SRI’s BioCyc™

  • Children spending more time on screens, going to bed later during pandemic
    June 6, 2022

    Children spending more time on screens, going to bed later during pandemic

    Data highlights the need to promote children’s balanced and informed use of digital technology for better sleep and behavior

  • Researchers use Oura Ring to study changes driven by the menstrual cycle
    April 27, 2022

    Researchers use Oura Ring to study changes driven by the menstrual cycle

    SRI Human Sleep Lab used Oura to study how cycle-related hormonal fluctuations might impact women

Featured innovators

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Parijat Bhatnagar

Program Director, Cell-based Medicine; Center for Chemical Biology

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Kathlynn Brown

Vice President, Drug Delivery Systems

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Massimiliano de Zambotti

Research Scientist, Human Sleep Research Program, Center for Health Sciences

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Peter Madrid

Vice President, SRI Biosciences

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Gita Shankar

Director, Formulations R&D, Pharmaceutical Sciences

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Michael Greenstein

Sensing and Diagnostics Lab Director, SRI Biosciences

Platforms

SRI Biosciences’ highly specialized platforms marry the advantages of our cutting-edge research with our flexible biotech business model. Partner with us to leverage our rigorous early discovery and development to customize your specific applications.

FOX Three Molecular Guidance System™

Cell-selective, intracellular delivery of macromolecular therapeutics: Deliver essentially any cargo to selected cell types, and internalize into those cells to targeted subcellular locations.

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Webinar

SynFini™

Suite of automated tools leverages AI to recreate and scale literature-reported synthesis procedures. Solutions focus on key areas of route design, reaction screening and optimization (RSO), and multi-step synthesis development.

Learn More
Webinar

Techneins™

Non-natural polymers as synthetic affinity reagents and novel therapeutics.

Learn More
Webinar

Fields of research

We work with commercial, government and academic clients and partners to help save and improve lives worldwide. Our leading-edge R&D is concentrated in the following areas to solve important problems in prevention, diagnosis and treatment.

  • Human sleep
  • Point of care diagnostics
  • Aging and neurodegenerative diseases
  • Neuroimaging and electrophysiological research
  • Blood brain barrier transport
  • Toxicology and safety
  • Homeland security/national defense
  • Immuno-oncology
  • Intracellular biologic therapies
  • Medical countermeasures
  • Formulation design
  • Biomarker discovery, development, validation

Collaborative models

SRI Biosciences takes on the toughest biomedical challenges with transformative approaches and platforms. We partner closely with clients in areas including:

  • Co-development/licensing
  • Federal subcontract teaming
  • Grant teaming
  • Incubator space and services
  • Joint business partnerships
  • Regulatory support
  • Technology platforms

“There are many talented researchers from various disciplines at SRI. This creates an exciting environment and fertile ground for cutting edge research thanks to the cooperation of different teams. This highly effective collaboration allows SRI to invent and develop unique and novel products and technologies.”

Michal Avital-Shmilovici

Research Scientist, Biosciences Division

michal-avital-shmilovici

Featured publications

more +

article
April 1, 2021

Performance of Fitbit Charge 3 Against Polysomnography in Measuring Sleep in Adolescent Boys and Girls

SRI Authors: Dilara Yüksel, Fiona C Baker, Massimiliano de Zambotti

JOURNAL ARTICLE
FEBRUARY 26, 2021

Physiological Responses to Acute Psychosocial Stress in Women with Menopausal Insomnia

SRI Authors: Dilara Yüksel, Massimiliano de Zambotti, Tilman Schulte, Ian M. Colrain, Fiona C Baker

ARTICLE
FEBRUARY 24, 2021

Sleep and Circadian Regulation of the Autonomic Nervous System

SRI Authors: Massimiliano de Zambotti, Fiona C Baker

Latest publications

more +

  • June 22, 2022

    Antiviral T-cell Biofactory platform for SARS-CoV-2

    We engineered a T cell to synthesize interferons (IFNs) as antiviral proteins upon recognizing the virus envelop protein of SARS-CoV-2, i.e., anti-SARS T-cell Biofactory.

  • June 15, 2022

    A virtual reality-based mind–body approach to downregulate psychophysiological arousal in adolescent insomnia

    A novel, digital, immersive virtual reality (VR)-based mind–body approach, designed to reduce bedtime arousal in adolescents with insomnia.

  • April 1, 2022

    Pathway Tools Management of Pathway/Genome Data for Microbial Communities

    The Pathway Tools software provides a suite of capabilities for storing and analyzing collections of genomic and metabolic information .

  • February 8, 2022

    Enhancement of sensitivity and quantification quality in the LC-MS/MS measurement of large biomolecules with sum of MRM (SMRM)

    We describe here an approach to boost detection sensitivity and expand dynamic range in the quantitation of large molecules while maintaining analytical specificity using summation of MRM (SMRM) transitions and LC separation technique.

  • August 30, 2021

    Physiological Synchrony: A New Approach Toward Identifying Unknown Presentation Attacks on Biometric Systems

    Here, we propose a new approach toward detecting unknown presentation attacks based on the measurement and characterization of synchrony between multiple physiological signals obtained from contact and contactless sensors.

  • July 9, 2021

    Cerebrospinal Fluid Monoamine Levels in Central Disorders of Hypersomnolence

    Whether the cause of daytime sleepiness in narcolepsy type 1 (NT1) is a direct consequence of the loss of orexin (ORX) neurons or whether low orexin reduces the efficacy of the monoaminergic systems to promote wakefulness is unclear.

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333 Ravenswood Ave
Menlo Park, CA 94025 USA

+1 (650) 859-2000

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