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Biomedical sciences

SRI Biosciences delivers next-generation drugs, diagnostics and devices to solve unmet medical needs. We work with partners to develop transformative approaches and platforms for the toughest therapeutic problems.

CONTACT US

Areas of expertise

Collaborative research

Neuroimaging and electrophysiological research

Sleep device design and validation

Adolescent development

Translational approaches using in vivo MRI

Translational neuroscience

Drug discovery

Technology platforms for new approaches to drug discovery

Small molecule and biologic therapies

AI-driven drug design

Target validation and assay development and screening

Lead identification, optimization and synthesis

Diagnostics and devices

Fiber-optic Array Scanning Technology (FAST) rare cell detection

High-speed hyperspectral imaging

Wearable sleep technology

Diagnostic biomarker discovery

SynFini: automated chemistry design and synthesis

Chemical and biological sensing solutions

Product development services

Pharmacology, efficacy and predictive ADMET

Safety, drug metabolism and pharmacokinetics

Formulation design

Clinical drug product manufacturing

Clinical trials

Our latest

more +
  • SRI’s radioactive contamination treatment is now in its first-in-human trial
    May 15, 2023

    SRI’s radioactive contamination treatment is now in its first-in-human trial

    The work, conducted by a multi-talented team of scientists, will provide critical data to help establish the safety of HOPO 14-1.

  • SRI researchers seek to produce food with just air, water, and electricity
    April 24, 2023

    SRI researchers seek to produce food with just air, water, and electricity

    Food from Air for Distributed Meals (FADR) seeks to produce nutritious food on-demand, aiding disaster relief efforts and military operations.

  • Kathlynn Brown: Creating real impact through your work
    March 7, 2023

    Kathlynn Brown: Creating real impact through your work

    A recognized leader in life sciences, SRI Bioscience’s first female president says passion and hard work are crucial in tackling difficult scientific challenges.

Featured innovators

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Kathlynn Brown

President, Biosciences Division

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Parijat Bhatnagar

Program Director, Cell-based Medicine; Center for Chemical Biology

massimiliano-de-zambotti-bio-pic

Massimiliano de Zambotti

Research Scientist, Human Sleep Research Program, Center for Health Sciences

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Peter Madrid

Vice President, SRI Biosciences

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Gita Shankar

Director, Formulations R&D, Pharmaceutical Sciences

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Michael Greenstein

Sensing and Diagnostics Lab Director, SRI Biosciences

Platforms

SRI Biosciences’ highly specialized platforms marry the advantages of our cutting-edge research with our flexible biotech business model. Partner with us to leverage our rigorous early discovery and development to customize your specific applications.

FOX Three Molecular Guidance System™

Cell-selective, intracellular delivery of macromolecular therapeutics: Deliver essentially any cargo to selected cell types, and internalize into those cells to targeted subcellular locations.

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Webinar

SynFini™

Suite of automated tools leverages AI to recreate and scale literature-reported synthesis procedures. Solutions focus on key areas of route design, reaction screening and optimization (RSO), and multi-step synthesis development.

Learn More
Webinar

Techneins™

A rapid discovery platform for non-natural polymers that expands our access to 3-dimensional structural diversity with the synthetic accessibility and optimizability of small molecules.

Learn More
Webinar

DiaCyt™

Identification of peptide-based delivery agents that can selectively transport molecular cargos into the central nervous system without physically disrupting the blood-brain barrier.

Learn More
Webinar

Fields of research

We work with commercial, government and academic clients and partners to help save and improve lives worldwide. Our leading-edge R&D is concentrated in the following areas to solve important problems in prevention, diagnosis and treatment.

  • Human sleep
  • Point of care diagnostics
  • Aging and neurodegenerative diseases
  • Neuroimaging and electrophysiological research
  • Blood brain barrier transport
  • Toxicology and safety
  • Homeland security/national defense
  • Immuno-oncology
  • Intracellular biologic therapies
  • Medical countermeasures
  • Formulation design
  • Biomarker discovery, development, validation

Collaborative models

SRI Biosciences takes on the toughest biomedical challenges with transformative approaches and platforms. We partner closely with clients in areas including:

  • Co-development/licensing
  • Federal subcontract teaming
  • Grant teaming
  • Incubator space and services
  • Joint business partnerships
  • Regulatory support
  • Technology platforms

“There are many talented researchers from various disciplines at SRI. This creates an exciting environment and fertile ground for cutting edge research thanks to the cooperation of different teams. This highly effective collaboration allows SRI to invent and develop unique and novel products and technologies.”

Michal Avital-Shmilovici

Research Scientist, Biosciences Division

michal-avital-shmilovici

Featured publications

more +

article
April 1, 2021

Performance of Fitbit Charge 3 Against Polysomnography in Measuring Sleep in Adolescent Boys and Girls

SRI Authors: Dilara Yüksel, Fiona C Baker, Massimiliano de Zambotti

JOURNAL ARTICLE
FEBRUARY 26, 2021

Physiological Responses to Acute Psychosocial Stress in Women with Menopausal Insomnia

SRI Authors: Dilara Yüksel, Massimiliano de Zambotti, Tilman Schulte, Ian M. Colrain, Fiona C Baker

ARTICLE
FEBRUARY 24, 2021

Sleep and Circadian Regulation of the Autonomic Nervous System

SRI Authors: Massimiliano de Zambotti, Fiona C Baker

Latest publications

more +
  • April 14, 2023

    Effects of emerging alcohol use on developmental trajectories of functional sleep measures in adolescents

    We tracked developmental changes in polysomnographic (PSG) and electroencephalographic (EEG) sleep measures and their relationship with emergent alcohol use in adolescents considering confounding effects (e.g., cannabis use).

  • March 30, 2023

    Association of Demographic and Socioeconomic Indicators With the Use of Wearable Devices Among Children

    We examined whether demographic and socioeconomic indicators are associated with willingness to join a wearable device study and adherence to wearable data collection in children.

  • March 28, 2023

    Emergence of terpene chemical communication in insects: Evolutionary recruitment of isoprenoid metabolism

    We present the first structural and mechanistic model for the evolutionary emergence of TPS function in insects. Through identifying key mechanistic differences between IDS and TPS enzymes, we hypothesize that the loss of isopentenyl diphosphate (IPP) binding motifs strongly correlates with the gain of the TPS function.

  • March 27, 2023

    Effects of the COVID-19 pandemic on screen time and sleep in early adolescents

    This study examined changes in sleep habits and recreational screen time (social media, video gaming), and their relationship, before and across the first year of the pandemic in adolescents in the Adolescent Brain Cognitive Development (ABCD) Study.

  • March 24, 2023

    Genetically engineered pair of cells for serological testing and its application for SARS-CoV-2

    We have developed a serology test platform for identifying individuals with prior exposure to specific viral infections and provide data to help reduce public health risks.

  • March 24, 2023

    The progression of radiation injury in a Wistar rat model of partial body irradiation with ∼5% bone marrow shielding

    Our purpose is to describe the dose response relationship and natural history of radiation injury in the Wistar rat and its suitability for use in medical countermeasures (MCM) testing.

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333 Ravenswood Ave
Menlo Park, CA 94025 USA

+1 (650) 859-2000

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