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SRI International - American Nonprofit Research Institute

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October 21, 2021

Biomedical sciences

SRI Biosciences delivers next-generation drugs, diagnostics and devices to solve unmet medical needs. We work with partners to develop transformative approaches and platforms for the toughest therapeutic problems.

Contact US

Some of our innovators

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Parijat Bhatnagar

Program Director, Cell-based Medicine; Center for Chemical Biology

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Kathlynn Brown

Senior Director, Macromolecular Sciences

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Massimiliano de Zambotti

Research Scientist, Human Sleep Research Program, Center for Health Sciences

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Peter Madrid

Senior Director and Head of Applied Biosciences

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Gita Shankar

Director, Formulations R&D, Pharmaceutical Sciences

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Michael Greenstein

Sensing and Diagnostics Lab Director, SRI Biosciences

Our latest

more +

COVID tied to a profound impact on children’s sleep

June 10, 2022

SRI’s Dr. Orsolya Kiss comments on findings from the ongoing ABCD study

8 year old on tablet with parent on phone in background

Teen screen time goes hand in hand with wacky bedtimes during the pandemic

June 9, 2022

SRI’s Dr. Kiss says urgent need to help families to formulate age-appropriate media use plans

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Children spending more time on screens, going to bed later during pandemic

June 6, 2022

Data highlights the need to promote children’s balanced and informed use of digital technology for better sleep and behavior

Areas of expertise

Collaborative research

Neuroimaging and electrophysiological research

Sleep device design and validation

Adolescent development

Translational approaches using in vivo MRI

Translational neuroscience

Drug discovery

Technology platforms for new approaches to drug discovery

Small molecule and biologic therapies

AI-driven drug design

Target validation and assay development and screening

Lead identification, optimization and synthesis

Diagnostics and devices

Fiber-optic Array Scanning Technology (FAST) rare cell detection

High-speed hyperspectral imaging

Wearable sleep technology

Diagnostic biomarker discovery

SynFini: automated chemistry design and synthesis

Chemical and biological sensing solutions

Product development services

Pharmacology, efficacy and predictive ADMET

Safety, drug metabolism and pharmacokinetics

Formulation design

Clinical drug product manufacturing

Clinical trials

Platforms

SRI Biosciences’ highly specialized platforms marry the advantages of our cutting-edge research with our flexible biotech business model. Partner with us to leverage our rigorous early discovery and development to customize your specific applications.

FOX Three Molecular Guidance System™

Cell-selective, intracellular delivery of macromolecular therapeutics: Deliver essentially any cargo to selected cell types, and internalize into those cells to targeted subcellular locations.

SynFini™

Suite of automated tools leverages AI to recreate and scale literature-reported synthesis procedures. Solutions focus on key areas of route design, reaction screening and optimization (RSO), and multi-step synthesis development.

Techneins™

Non-natural polymers as synthetic affinity reagents and novel therapeutics

Synthetic Lethals

AI-guided precision cancer therapy platform provides a new approach to finding targeted therapies for previously “undruggable mutations.”

Fields of research

We work with commercial, government and academic clients and partners to help save and improve lives worldwide. Our leading-edge R&D is concentrated in the following areas to solve important problems in prevention, diagnosis and treatment.

  • Human sleep
  • Point of care diagnostics
  • Aging and neurodegenerative diseases
  • Neuroimaging and electrophysiological research
  • Blood brain barrier transport
  • Toxicology and safety
  • Homeland security/national defense
  • Immuno-oncology
  • Intracellular biologic therapies
  • Medical countermeasures
  • Formulation design
  • Biomarker discovery, development, validation

Collaborative models

SRI Biosciences takes on the toughest biomedical challenges with transformative approaches and platforms. We partner closely with clients in areas including:

  • Co-development/licensing
  • Federal subcontract teaming
  • Grant teaming
  • Incubator space and services
  • Joint business partnerships
  • Regulatory support
  • Technology platforms

“There are many talented researchers from various disciplines at SRI. This creates an exciting environment and fertile ground for cutting edge research thanks to the cooperation of different teams. This highly effective collaboration allows SRI to invent and develop unique and novel products and technologies.”

Michal Avital-Shmilovici

Research Scientist, Biosciences Division

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Featured publications

more +

article
April 1, 2021

Performance of Fitbit Charge 3 Against Polysomnography in Measuring Sleep in Adolescent Boys and Girls

SRI Authors: Dilara Yüksel, Fiona C Baker, Massimiliano de Zambotti

JOURNAL ARTICLE
FEBRUARY 26, 2021

Physiological Responses to Acute Psychosocial Stress in Women with Menopausal Insomnia

SRI Authors: Dilara Yüksel, Massimiliano de Zambotti, Tilman Schulte, Ian M. Colrain, Fiona C Baker

ARTICLE
FEBRUARY 24, 2021

Sleep and Circadian Regulation of the Autonomic Nervous System

SRI Authors: Massimiliano de Zambotti, Fiona C Baker

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