Areas of expertise
Collaborative research
Neuroimaging and electrophysiological research
Sleep device design and validation
Adolescent development
Translational approaches using in vivo MRI
Translational neuroscience
Drug discovery
Technology platforms for new approaches to drug discovery
Small molecule and biologic therapies
AI-driven drug design
Target validation and assay development and screening
Lead identification, optimization and synthesis
Diagnostics and devices
Fiber-optic Array Scanning Technology (FAST) rare cell detection
High-speed hyperspectral imaging
Wearable sleep technology
Diagnostic biomarker discovery
SynFini: automated chemistry design and synthesis
Chemical and biological sensing solutions
Product development services
Pharmacology, efficacy and predictive ADMET
Safety, drug metabolism and pharmacokinetics
Formulation design
Clinical drug product manufacturing
Clinical trials
Our latest
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An SRI scientist shares glycomics protocols with the scientific community
Denong Wang of SRI’s Tumor Glycomics Lab discusses strategies to explore sugar chain signatures of microbes and cancers.
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Exploring the deep connections between adolescent sleep and overall health
Fiona Baker of SRI’s Human Sleep Lab discusses how good sleep patterns are critical for brain development in our early years.
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SRI seeks to learn how insects speak through smells
Understanding chemical communication among insects could help find new ways to protect crops or ward off biting insects that can transmit diseases.
Featured innovators
Platforms
SRI Biosciences’ highly specialized platforms marry the advantages of our cutting-edge research with our flexible biotech business model. Partner with us to leverage our rigorous early discovery and development to customize your specific applications.
FOX Three Molecular Guidance System™
Cell-selective, intracellular delivery of macromolecular therapeutics: Deliver essentially any cargo to selected cell types, and internalize into those cells to targeted subcellular locations.
SynFini™
Suite of automated tools leverages AI to recreate and scale literature-reported synthesis procedures. Solutions focus on key areas of route design, reaction screening and optimization (RSO), and multi-step synthesis development.
Techneins™
A rapid discovery platform for non-natural polymers that expands our access to 3-dimensional structural diversity with the synthetic accessibility and optimizability of small molecules.
DiaCyt™
Identification of peptide-based delivery agents that can selectively transport molecular cargos into the central nervous system without physically disrupting the blood-brain barrier.
Fields of research
We work with commercial, government and academic clients and partners to help save and improve lives worldwide. Our leading-edge R&D is concentrated in the following areas to solve important problems in prevention, diagnosis and treatment.
- Human sleep
- Point of care diagnostics
- Aging and neurodegenerative diseases
- Neuroimaging and electrophysiological research
- Blood brain barrier transport
- Toxicology and safety
- Homeland security/national defense
- Immuno-oncology
- Intracellular biologic therapies
- Medical countermeasures
- Formulation design
- Biomarker discovery, development, validation
Collaborative models
SRI Biosciences takes on the toughest biomedical challenges with transformative approaches and platforms. We partner closely with clients in areas including:
- Co-development/licensing
- Federal subcontract teaming
- Grant teaming
- Incubator space and services
- Joint business partnerships
- Regulatory support
- Technology platforms
“There are many talented researchers from various disciplines at SRI. This creates an exciting environment and fertile ground for cutting edge research thanks to the cooperation of different teams. This highly effective collaboration allows SRI to invent and develop unique and novel products and technologies.”
Michal Avital-Shmilovici
Research Scientist, Biosciences Division
Latest publications
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Survival and Hematologic Benefits of Romiplostim After Acute Radiation Exposure Supported FDA Approval Under the Animal Rule
The goal of our study was to evaluate the postirradiation survival and hematologic benefits of a single dose of RP with or without pegfilgrastim.
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Bedtime screen use behaviors and sleep outcomes: Findings from the Adolescent Brain Cognitive Development (ABCD) Study
We aim to determine associations between bedtime screen time behaviors and sleep outcomes in a national study of early adolescents.
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Effects of emerging alcohol use on developmental trajectories of functional sleep measures in adolescents
We tracked developmental changes in polysomnographic (PSG) and electroencephalographic (EEG) sleep measures and their relationship with emergent alcohol use in adolescents considering confounding effects (e.g., cannabis use).
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Association of Demographic and Socioeconomic Indicators With the Use of Wearable Devices Among Children
We examined whether demographic and socioeconomic indicators are associated with willingness to join a wearable device study and adherence to wearable data collection in children.
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Emergence of terpene chemical communication in insects: Evolutionary recruitment of isoprenoid metabolism
We present the first structural and mechanistic model for the evolutionary emergence of TPS function in insects. Through identifying key mechanistic differences between IDS and TPS enzymes, we hypothesize that the loss of isopentenyl diphosphate (IPP) binding motifs strongly correlates with the gain of the TPS function.
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Effects of the COVID-19 pandemic on screen time and sleep in early adolescents
This study examined changes in sleep habits and recreational screen time (social media, video gaming), and their relationship, before and across the first year of the pandemic in adolescents in the Adolescent Brain Cognitive Development (ABCD) Study.