Areas of expertise
Collaborative research
Neuroimaging and electrophysiological research
Sleep device design and validation
Adolescent development
Translational approaches using in vivo MRI
Translational neuroscience
Drug discovery
Technology platforms for new approaches to drug discovery
Small molecule and biologic therapies
AI-driven drug design
Target validation and assay development and screening
Lead identification, optimization and synthesis
Diagnostics and devices
Fiber-optic Array Scanning Technology (FAST) rare cell detection
High-speed hyperspectral imaging
Wearable sleep technology
Diagnostic biomarker discovery
SynFini: automated chemistry design and synthesis
Chemical and biological sensing solutions
Product development services
Pharmacology, efficacy and predictive ADMET
Safety, drug metabolism and pharmacokinetics
Formulation design
Clinical drug product manufacturing
Clinical trials
Our latest
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Kathlynn Brown: Creating real impact through your work
A recognized leader in life sciences, SRI Bioscience’s first female president says passion and hard work are crucial in tackling difficult scientific challenges.
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SRI scientists are developing therapeutics to help fight the next pandemic
The institute received a four-year, $4.95 million award from the National Institute of Allergy and Infectious Diseases.
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Scientists at SRI International have developed a peptide that targets lung tumors and delivers therapeutics inside the cells
The newly optimized molecular vehicle provides effective, targeted delivery of anticancer agents to lung tumors.
Featured innovators
Platforms
SRI Biosciences’ highly specialized platforms marry the advantages of our cutting-edge research with our flexible biotech business model. Partner with us to leverage our rigorous early discovery and development to customize your specific applications.
FOX Three Molecular Guidance System™
Cell-selective, intracellular delivery of macromolecular therapeutics: Deliver essentially any cargo to selected cell types, and internalize into those cells to targeted subcellular locations.
SynFini™
Suite of automated tools leverages AI to recreate and scale literature-reported synthesis procedures. Solutions focus on key areas of route design, reaction screening and optimization (RSO), and multi-step synthesis development.
Techneins™
A rapid discovery platform for non-natural polymers that expands our access to 3-dimensional structural diversity with the synthetic accessibility and optimizability of small molecules.
DiaCyt™
Identification of peptide-based delivery agents that can selectively transport molecular cargos into the central nervous system without physically disrupting the blood-brain barrier.
Fields of research
We work with commercial, government and academic clients and partners to help save and improve lives worldwide. Our leading-edge R&D is concentrated in the following areas to solve important problems in prevention, diagnosis and treatment.
- Human sleep
- Point of care diagnostics
- Aging and neurodegenerative diseases
- Neuroimaging and electrophysiological research
- Blood brain barrier transport
- Toxicology and safety
- Homeland security/national defense
- Immuno-oncology
- Intracellular biologic therapies
- Medical countermeasures
- Formulation design
- Biomarker discovery, development, validation
Collaborative models
SRI Biosciences takes on the toughest biomedical challenges with transformative approaches and platforms. We partner closely with clients in areas including:
- Co-development/licensing
- Federal subcontract teaming
- Grant teaming
- Incubator space and services
- Joint business partnerships
- Regulatory support
- Technology platforms
“There are many talented researchers from various disciplines at SRI. This creates an exciting environment and fertile ground for cutting edge research thanks to the cooperation of different teams. This highly effective collaboration allows SRI to invent and develop unique and novel products and technologies.”
Michal Avital-Shmilovici
Research Scientist, Biosciences Division
Latest publications
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Association of Demographic and Socioeconomic Indicators With the Use of Wearable Devices Among Children
We examined whether demographic and socioeconomic indicators are associated with willingness to join a wearable device study and adherence to wearable data collection in children.
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Emergence of terpene chemical communication in insects: Evolutionary recruitment of isoprenoid metabolism
We present the first structural and mechanistic model for the evolutionary emergence of TPS function in insects. Through identifying key mechanistic differences between IDS and TPS enzymes, we hypothesize that the loss of isopentenyl diphosphate (IPP) binding motifs strongly correlates with the gain of the TPS function.
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Effects of the COVID-19 pandemic on screen time and sleep in early adolescents
This study examined changes in sleep habits and recreational screen time (social media, video gaming), and their relationship, before and across the first year of the pandemic in adolescents in the Adolescent Brain Cognitive Development (ABCD) Study.
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Genetically engineered pair of cells for serological testing and its application for SARS-CoV-2
We have developed a serology test platform for identifying individuals with prior exposure to specific viral infections and provide data to help reduce public health risks.
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Good Sleep is a Mood Buffer for Young Women During Menses
We sought to elucidate the interaction between sleep and mood considering menstrual cycle phase in 72 healthy young women with natural, regular menstrual cycles and without menstrual-associated disorders.
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Activation of the nociceptin/orphanin-FQ receptor promotes NREM sleep and EEG slow wave activity
In the present study, we systematically evaluated the efficacy of two NOPR agonists, Ro64-6198 and SR16835, on sleep/wake in rats, mice, and Cynomolgus macaques.