Areas of expertise
Collaborative research
Neuroimaging and electrophysiological research
Sleep device design and validation
Adolescent development
Translational approaches using in vivo MRI
Translational neuroscience
Drug discovery
Technology platforms for new approaches to drug discovery
Small molecule and biologic therapies
AI-driven drug design
Target validation and assay development and screening
Lead identification, optimization and synthesis
Diagnostics and devices
Fiber-optic Array Scanning Technology (FAST) rare cell detection
High-speed hyperspectral imaging
Wearable sleep technology
Diagnostic biomarker discovery
SynFini: automated chemistry design and synthesis
Chemical and biological sensing solutions
Product development services
Pharmacology, efficacy and predictive ADMET
Safety, drug metabolism and pharmacokinetics
Formulation design
Clinical drug product manufacturing
Clinical trials
Our latest
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Ovid adds BioCyc Pathway/Genome Databases to support genomic researchers
To increase researchers’ access to comprehensive data, Wolters Kluwer expanded Ovid® with SRI’s BioCyc™
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Children spending more time on screens, going to bed later during pandemic
Data highlights the need to promote children’s balanced and informed use of digital technology for better sleep and behavior
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Researchers use Oura Ring to study changes driven by the menstrual cycle
SRI Human Sleep Lab used Oura to study how cycle-related hormonal fluctuations might impact women
Featured innovators
Platforms
SRI Biosciences’ highly specialized platforms marry the advantages of our cutting-edge research with our flexible biotech business model. Partner with us to leverage our rigorous early discovery and development to customize your specific applications.
FOX Three Molecular Guidance System™
Cell-selective, intracellular delivery of macromolecular therapeutics: Deliver essentially any cargo to selected cell types, and internalize into those cells to targeted subcellular locations.
SynFini™
Suite of automated tools leverages AI to recreate and scale literature-reported synthesis procedures. Solutions focus on key areas of route design, reaction screening and optimization (RSO), and multi-step synthesis development.
Fields of research
We work with commercial, government and academic clients and partners to help save and improve lives worldwide. Our leading-edge R&D is concentrated in the following areas to solve important problems in prevention, diagnosis and treatment.
- Human sleep
- Point of care diagnostics
- Aging and neurodegenerative diseases
- Neuroimaging and electrophysiological research
- Blood brain barrier transport
- Toxicology and safety
- Homeland security/national defense
- Immuno-oncology
- Intracellular biologic therapies
- Medical countermeasures
- Formulation design
- Biomarker discovery, development, validation
Collaborative models
SRI Biosciences takes on the toughest biomedical challenges with transformative approaches and platforms. We partner closely with clients in areas including:
- Co-development/licensing
- Federal subcontract teaming
- Grant teaming
- Incubator space and services
- Joint business partnerships
- Regulatory support
- Technology platforms
“There are many talented researchers from various disciplines at SRI. This creates an exciting environment and fertile ground for cutting edge research thanks to the cooperation of different teams. This highly effective collaboration allows SRI to invent and develop unique and novel products and technologies.”
Michal Avital-Shmilovici
Research Scientist, Biosciences Division
Latest publications
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Antiviral T-cell Biofactory platform for SARS-CoV-2
We engineered a T cell to synthesize interferons (IFNs) as antiviral proteins upon recognizing the virus envelop protein of SARS-CoV-2, i.e., anti-SARS T-cell Biofactory.
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A virtual reality-based mind–body approach to downregulate psychophysiological arousal in adolescent insomnia
A novel, digital, immersive virtual reality (VR)-based mind–body approach, designed to reduce bedtime arousal in adolescents with insomnia.
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Pathway Tools Management of Pathway/Genome Data for Microbial Communities
The Pathway Tools software provides a suite of capabilities for storing and analyzing collections of genomic and metabolic information .
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Enhancement of sensitivity and quantification quality in the LC-MS/MS measurement of large biomolecules with sum of MRM (SMRM)
We describe here an approach to boost detection sensitivity and expand dynamic range in the quantitation of large molecules while maintaining analytical specificity using summation of MRM (SMRM) transitions and LC separation technique.
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Physiological Synchrony: A New Approach Toward Identifying Unknown Presentation Attacks on Biometric Systems
Here, we propose a new approach toward detecting unknown presentation attacks based on the measurement and characterization of synchrony between multiple physiological signals obtained from contact and contactless sensors.
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Cerebrospinal Fluid Monoamine Levels in Central Disorders of Hypersomnolence
Whether the cause of daytime sleepiness in narcolepsy type 1 (NT1) is a direct consequence of the loss of orexin (ORX) neurons or whether low orexin reduces the efficacy of the monoaminergic systems to promote wakefulness is unclear.