Massimiliano de Zambotti

Research Scientist, Human Sleep Research Program, Center for Health Sciences

Massimiliano de Zambotti, Ph.D., joined SRI International in 2012 and is currently leading the Translational Sleep Technology Unit of the Human Sleep Research Program. His work focuses on the interactions between the autonomic and central nervous systems in different psychophysiological states (e.g., sleep and wake state, menstrual cycle phases and reproductive hormonal environments), in clinical and non-clinical populations (e.g., insomnia disorder, alcohol use disorder). De Zambotti is devoted to the mission of advancing science, discovering and developing novel approaches and technologies to improve people’s health and well-being. 

His expertise is in the areas of normal and pathologic sleep, sleep technology development and testing, autonomic nervous system regulation during sleep and interactions between sleep, autonomic and endocrine systems, menopause, hot flashes and wearable technology. de Zambotti leads validation studies of wearable technologies in the sleep space and the development of novel technologies such as non-pharmacological wearable devices to monitor sleep and bio-signals and improve sleep quality.

de Zambotti is also co-founder and chief scientific officer of digital health platform and SRI spin-out Lisa Health, which utilizes AI and wearable technology to transform the menopause and healthy aging journey. He has investigated and developed novel technology for menopause, including automatic detection and prediction of hot flashes in menopausal women, sleep disturbance associated with hot flashes, and immersive meditation as a novel evidence-based intervention for various menopause symptoms.

 He is currently PI on two NIH-funded projects, one about sleep and cardiovascular health in adolescents (R01 HL139652), and the other about alcohol, sleep, and autonomic nervous system function in adults (R21 AA024841).

de Zambotti has published more than 40 international peer-reviewed papers. He obtained a MSc in experimental psychology and cognitive-behavioral neurosciences in 2007 and a Ph.D. in psychological sciences (biological psychology) in 2011, from the University of Padua, Italy.

View de Zambotti’s publications on Research Gate and Google Scholar.

YouTube player

Recent publications

more +

Read more from SRI