A chemical assessment and HPLC assay validation of bulk paromomycin sulfate


L. Olson, J. Pick, W. Ellis and P. Lim. A Chemical Assessment and HPLC Assay Validation of Bulk Paromomycin Sulfate. Journal of Pharmaceutical and Biomedical Analysis, vol. 15, p. 783, 1997.


This paper describes the compositional analyses of four paromomycin sulfate samples and features a validated HPLC assay method that relies on the fluorescence detection of isoindole derivatives of paromomycin, formed by post-column reaction with o-phthalaldehyde and 2-mercaptoethanol.

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