• Skip to primary navigation
  • Skip to main content
SRI logo
  • About
    • Press room
    • Our history
  • Expertise
    • Advanced imaging systems
    • Artificial intelligence
    • Biomedical R&D services
    • Biomedical sciences
    • Computer vision
    • Cyber & formal methods
    • Education and learning
    • Innovation strategy and policy
    • National security
    • Ocean & space
    • Quantum
    • Robotics, sensors & devices
    • Speech & natural language
    • Video test & measurement
  • Ventures
  • NSIC
  • Careers
  • Contact
  • 日本支社
Search
Close
Biomedical sciences publications July 1, 2008

Neuroinflammation as a Neurotoxic Mechanism in Alcoholism: Commentaryon “Increased Mcp-1 and Microglia in Various Regions of Human Alcoholic Brain”

Citation

Copy to clipboard


Sullivan, E. V., & Zahr, N. M. (2008). Commentary on “Increased MCP-1 and Microglia in Various regions of Human Alcoholic Brain”. Experimental neurology, 213(1), 10.

Introduction

A potential mechanism of the neurotoxic effects of chronic excessive alcohol consumption

The study by He and Crews (2008) is a hypothesis-driven work with the objective of isolating a potential mechanism of neural damage caused by extensive, chronic alcohol consumption. To this end, the authors obtained human brain tissue of alcoholics and moderate drinking controls from the New South Wales Tissue Resource Center, which provided a clinical characterization through systematic postmortem “interview” (Harper et al., 2003a, Harper et al., 2003b). Markers of inflammation sought were…

Neuropathological evidence

Neuropathological studies of chronic alcoholism indicate that loss of neurons is selective to frontal cortex (Courville, 1955, Harper and Kril, 1990) with little evidence for widespread cell loss (Harper, 1998, Harper et al., 1987, Kril and Harper, 1989). Although more recent work using TUNEL staining, an indicator of damaged DNA and potentially indicative of apoptosis, reveals TUNEL-positive cells in the superior frontal cortex of human alcoholics, rarely observed in control brains,…

How He and Crews fill a lacuna of evidence for alcoholism neurotoxicity

The hypothesis tested by He and Crews was that alcohol induces inflammatory processes in the brain leading to neurodegeneration. To the extent that He and Crews sought to demonstrate an overly active immune response in the brains of alcoholics compared with controls, they were successful. Greater expression of MCP-1, Iba-1, or GluT5 in several brain regions of alcoholics relative to controls supports the concept that neuroinflammation occurs in response to chronic and excessive alcohol…

Significance of basic research on alcoholism to medicine and society

According to the 2001-2 National Epidemiologic Survey on Alcohol and Related Conditions (NESARC), more than 20% of men, age 18 to 29, met criteria for a diagnosable alcohol use disorder (AUD): 9.3% Alcohol Abuse and 13% Alcohol Dependence. The lower prevalence in women and a declining prevalence with older age reduce the population-wide mean prevalence of an AUD in the past year to less than 10% (Grant et al., 2004). The socioeconomic, health, and mortality costs of alcohol use in the US,…

↓ View online

Share this
Career call to action image

Work with us

Search jobs

How can we help?

Once you hit send…

We’ll match your inquiry to the person who can best help you.

Expect a response within 48 hours.

Our work

Case studies

Publications

Timeline of innovation

Areas of expertise

Institute

Leadership

Press room

Media inquiries

Compliance

Careers

Job listings

Contact

SRI Ventures

Our locations

Headquarters

333 Ravenswood Ave
Menlo Park, CA 94025 USA

+1 (650) 859-2000

Subscribe to our newsletter


日本支社
SRI International
  • Contact us
  • Privacy Policy
  • Cookies
  • DMCA
  • Copyright © 2023 SRI International
Manage Cookie Consent
To provide the best experiences, we use technologies like cookies to store and/or access device information. Consenting to these technologies will allow us to process data such as browsing behavior or unique IDs on this site. Not consenting or withdrawing consent, may adversely affect certain features and functions.
Functional Always active
The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.
Preferences
The technical storage or access is necessary for the legitimate purpose of storing preferences that are not requested by the subscriber or user.
Statistics
The technical storage or access that is used exclusively for statistical purposes. The technical storage or access that is used exclusively for anonymous statistical purposes. Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you.
Marketing
The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes.
Manage options Manage services Manage {vendor_count} vendors Read more about these purposes
View preferences
{title} {title} {title}