Gerashchenko D, Wisor JP, Kilduff TS (2011). Sleep-active Cells in the Cerebral Cortex and Their Role in Slow-Wave Activity. Sleep and Biological Rhythms 9: 71-77. PMID: 21625335; PMC3103062.
We recently identified neurons in the cerebral cortex that become activated during sleep episodes with high slow-wave activity (SWA). The distinctive properties of these neurons are the ability to produce nitric oxide and their long-range projections within the cortex. In this review, we discuss how these characteristics of sleep-active cells could be relevant to SWA production in the cortex. We also discuss possible models of the role of nNOS cells in SWA production.