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Journal Article  January 1, 2018

The MetaCyc database of metabolic pathways and enzymes

SRI Authors Mario Latendresse, Manish Kothari, Peter Karp



Caspi, R., Billington, R., Fulcher, C.A., Keseler, I.M., Kothari, A., Krummenacker, M., Latendresse, M., Midford, P.E., Ong, Q., Ong, W.K., Paley, S., Subhraveti, P., & Karp, P.D. (2018). The MetaCyc database of metabolic pathways and enzymes. Nucleic Acids Research. Vol. 46(D1):D633–D639. DOI: 10.1093/nar/gkx935


MetaCyc ( is a comprehensive reference database of metabolic pathways and enzymes from all domains of life. It contains more than 2570 pathways derived from >54 000 publications, making it the largest curated collection of metabolic pathways. The data in MetaCyc is strictly evidence-based and richly curated, resulting in an encyclopedic reference tool for metabolism. MetaCyc is also used as a knowledge base for generating thousands of organism-specific Pathway/Genome Databases (PGDBs), which are available in the BioCyc ( and other PGDB collections. This article provides an update on the developments in MetaCyc during the past two years, including the expansion of data and addition of new features.

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