Author: SRI International
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Compound Ranking Based on a New Mathematical Measure of Effectiveness Using Time Course Data from Cell-Based Assays
This article proposes a new approach to measure drug effectiveness, which allows ranking compounds according to their toxic effects on live cells.
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Crossing the Valley of Death: Transitioning Cybersecurity Research into Practice
This article presents an R&D execution model to increase the success rate of technology transition along with several examples of successful technology transition from the US Department of Homeland Security Science and Technology Directorate’s cybersecurity R&D program.
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TB Mobile: A Mobile App for Anti-Tuberculosis Molecules with Known Targets
In order to learn from prior work we have collated information on molecules screened versus Mtb and their targets which has been made available in the Collaborative Drug Discovery (CDD) database.
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Biomarkers—an Essential Tie That Binds the Future of Drugs and Diagnostics
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Maximizing Availability of Content in Disruptive Environments by Cross-Layer Optimization
Inspired by delay- and disruption-tolerant networking, this paper presents a distributed cross-layer monitoring and optimization method for secure content delivery as a first step toward decentralized content-based mobile ad hoc networking.
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Restoration and Recognition of Distant, Blurry Irises
Here we apply a pure digital image restoration approach to correct for optical aberrations. Image restoration was applied to both single images and image sequences. We propose both a single-frame denoising and deblurring approach, and a multiframe fusion and deblurring approach.
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Legal, Technical, and Interpretational Considerations in the Forensic Analysis of Viruses
This review provides a general approach to viral forensics, especially in light of significant biodefense challenges.
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The Nicotine-Mediated Decline in L-Dopa-Induced Dyskinesias Is Associated with a Decrease in Striatal Dopamine Release
This study investigates whether nicotine may exert its beneficial effects by modulating pre-synaptic dopaminergic function.
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Ferritin and Ferrihydrite Nanoparticles as Iron Sources for Pseudomonas Aeruginosa
The ability of Pseudomonas aeruginosa to acquire iron from exogenous ferritin was assessed; ferritin is an iron-concentrating and antioxidant protein complex composed of a catalytic protein and caged ferrihydrite nanomineral synthesized from Fe(II) and O2 or H2O2.
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Ion Gyro-Harmonic Structuring in the Stimulated Radiation Spectrum and Optical Emissions During Electron Gyro-Harmonic Heating
The first extensive systematic experimental investigations of the possibility of these spectral features for third electron gyro-harmonic heating are provided here
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Proteolytic Enzymes as Biomarkers of Focal Segmental Glomerulosclerosis
Here, the library was utilized to map the global proteolytic specificities of plasma samples obtained from patients with the nephrotic syndrome, known as focal segmental glomerulosclerosis (FSGS).
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The Characteristics of the O-2 Herzberg Ii and Chamberlain Bands Observed with Virtis/Venus Express
Recent observations with the VIRTIS instrument on board Venus Express allowed us to re-examine the Herzberg II system of O2 and to further study its vertical distribution, in particular the (0–m00 with m00 = 7–13) bands.