Author: SRI International
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Immunoregulatory and Effector Activities in Human Cutaneous and Mucosal Leishmaniasis: Understanding Mechanisms of Pathology
By studying the immune response from CL and ML patients in both the peripheral blood and in situ, we have learned much concerning the dynamics of the host–pathogen interaction that leads to the development of CL and ML.
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Providing Coaching and Cotinine Results to Preteens to Reduce Their Secondhand Smoke Exposure: a Randomized Trial
This trial determined whether coaching and cotinine feedback provided to preteens can reduce their SHSe.
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The Electron Density Dependence of Polar Mesospheric Summer Echoes
We present several observations made using the Poker Flat Incoherent Scatter Radar which are difficult to explain based on those expressions, including observations at night with no detectable incoherent scatter below 90 km and during aurora where the reflectivity shows no response to abrupt changes in ionization.
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A Fluoroquinolone-Resistant Acinetobacter Baumannii Without the Quinolone Resistance-Determining Region Mutations
To address the progression of antibiotic resistance in A. baumannii ATCC 17978, we attempted to isolate A. baumannii ATCC 17978 ciprofloxacin-resistant mutants…
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Targeting Nicotinic Receptors for Parkinson’s Disease Therapy
Experimental work in parkinsonian animal models suggests that nicotine in tobacco may contribute to this protection. These combined findings suggest that nicotine and nAChR drugs offer the possibility of improved therapeutics for Parkinson’s disease.
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The Biason the Joule Heating Estimate: Small-Scale Variability Versus Resolved-Scale Model Uncertainty and the Correlation of Electric Field and Conductance
In this work we separately analyze the small-scale variability and the resolved-scale model uncertainty using the Sondrestrom radar database, and we find that each gives a significant contribution to the bias on Joule heating.
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Tracking Group Targets Using Hypergraph Matching in Data Association
This paper reformulates the traditional MTT data association problem as an hypergraph matching one between the hypergraphs formed from tracks and observations, and shows that the traditional approach which is a special case under the proposed framework.
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CD4(+) T Cells Defined By Their V Beta T Cell Receptor Expression Are Associated with Immunoregulatory Profiles and Lesion Size in Human Leishmaniasis
In order to measure the host T cell response to Leishmania infection, we have measured the expansion, activation state and functional potential of specific T cells as identified by their T cell receptor Vβ region expression.
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Climate-Monitoring Cubesat Mission (Cm2): a Project for Global Mesopause Temperature Sensing
This paper outlines an instrument to advance the state of the art in atmospheric climate projection by providing critical global measurements of middle-atmosphere temperatures and waves with a CubeSatscale imaging spectrograph.
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A Graph Traversal Based Algorithm for Obstacle Detection Using Lidar or Stereo
We present a novel computationally efficient approach to obstacle detection that is applicable to both structured and unstructured environments.
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Analytical Methods for the Bioavailability Evaluation of Hydroxypryridinonate Actinide Decorporation Agents in Pre-clinical Pharmacokinetic Studies
The described bioanalytical detection methods were successfully applied to the selection of solid-state forms of 5-LIO and 3,4,3-LI for future preclinical development activities, and will be adapted for use with plasma from other species.
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Clinical Aspects of Chagas Disease and Implications for Novel Therapies
The interaction between the protozoan parasite Trypanosoma cruzi and the human host dates back 9,000 years, as demonstrated by molecular analysis of material obtained from Andean mummies indicating the presence of the parasite’s kinetoplast DNA in populations from Chile and Peru.