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Bios September 8, 2021

Peter Karp

Technical Director, Artificial Intelligence Center

Peter Karp, Ph.D., Technical Director of the Bioinformatics Research Group at SRI International, works in the interdisciplinary field of bioinformatics, which develops computer-science methods for managing and analyzing the burgeoning quantities of biological data and knowledge.

Karp has been a pioneer in metabolic-pathway bioinformatics. His group has developed a metabolic-pathway database called EcoCyc that charts the complete biochemical factory within an Escherichia coli cell. His group has also developed algorithms for visualization of metabolic networks, for predicting anti-bacterial drug targets within metabolic networks, and for predicting the metabolic pathways of an organism whose genome has been sequenced. The latter algorithm has been applied to thousands of organisms to produce the BioCyc database collection.

Karp has authored more than 190 publications in computer science and  bioinformatics.  He is an SRI Fellow, a Fellow of the International Society for Computational Biology, and a Fellow of the American Association for the Advancement of Science.

Recent publications

more +

Pathway Tools Management of Pathway/Genome Data for Microbial Communities (4/1/2022) - The Pathway Tools software provides a suite of capabilities for storing and analyzing collections of genomic and metabolic information .
Metabolic Modeling with MetaFlux  (10/31/2021) - The MetaFlux software supports creating, executing, and solving quantitative metabolic flux models using flux balance analysis (FBA).
The EcoCyc Database in 2021 (7/1/2021) - This article highlights recent improvements to the curated data in the areas of metabolism, transport, DNA repair, and regulation of…
The BioCyc Metabolic Network Explorer (4/1/2021) - The Metabolic Network Explorer is a new addition to the BioCyc.org website and the Pathway Tools software suite that supports…
Pathway Size Matters: The Influence of Pathway Granularity on Over-Representation (Enrichment) Statistics (3/1/2021) - We show that alternative pathway definitions can alter enrichment p -values by up to nine orders of magnitude, whereas statistical…
Leveraging Curation Among Escherichia coli Pathway/Genome Databases Using Ortholog-Based Annotation Propagation (3/1/2021) - We have developed a method to automatically propagate multiple types of curated knowledge from genes and proteins in one genome…

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