J. Pick, L. Olson, W. Ellis and P. Lim. Development and validation of a method to extract and quantitate paromomycin and gentamicin from an Aquaphillic® cream formulation. Journal of Pharmaceutical and Biomedical Analysis, vol. 16, p. 131, 1997.
Butanol and dilute sulfuric acid were used to extract paromomycin and gentamicin from Aquaphilic®-based formulated creams. The extraction procedure was validated over different antibiotic concentration ranges for linearity, precision, accuracy, limited specificity, sensitivity and solution stability.