Citation
Hickson, R., Hebron, L., Müller-Oehring, E.M., Cheu, A., Hernandez, A., Kiss, O., Gombert-Labedens, M., Baker, F.C., Schulte T. (2024). Resting-state fMRI activation is associated with phenotypic features of autism in early adolescence. Frontiers in Child and Adolescent Psychiatry, section Autism and Other Neurodevelopmental Disorders. Accepted 10-21-2024.
Abstract
Autism Spectrum Disorder (ASD) is characterized by deficits in social cognition, self-referential processing, and restricted repetitive behaviors. Despite the established clinical symptoms and neurofunctional alterations in ASD, definitive biomarkers for ASD features during neurodevelopment remain unknown. In this study, we aimed to explore if activation in brain regions of the default mode network (DMN), specifically the medial prefrontal cortex (MPC), posterior cingulate cortex (PCC), superior temporal sulcus (STS), inferior frontal gyrus (IFG), angular gyrus (AG), and the temporoparietal junction (TPJ), during resting-state functional magnetic resonance imaging (rs-fMRI) is associated with possible phenotypic features of autism (PPFA) in a large, diverse youth cohort.
